B5YD88

PR
Gene name
lig
Protein name
Probable DNA ligase
Names
Polydeoxyribonucleotide synthase [ATP]
Species
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
KEGG Pathway
dth:DICTH_0616
EC number
6.5.1.1: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-159 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5YD88

Entry ID Method Resolution Chain Position Source
AF-B5YD88-F1 Predicted AlphaFoldDB

No variants for B5YD88

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5YD88

No associated diseases with B5YD88

11 regional properties for B5YD88

Type Name Position InterPro Accession
domain Protein kinase domain 626 - 887 IPR000719
domain Ephrin receptor ligand binding domain 29 - 210 IPR001090
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 626 - 883 IPR001245
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 186 - 206 IPR001426-1
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 247 - 267 IPR001426-2
domain Sterile alpha motif domain 907 - 974 IPR001660
domain Fibronectin type III 328 - 533 IPR003961
active_site Tyrosine-protein kinase, active site 747 - 759 IPR008266
binding_site Protein kinase, ATP binding site 632 - 658 IPR017441
domain Tyrosine-protein kinase, catalytic domain 626 - 883 IPR020635
domain Ephrin receptor, transmembrane domain 548 - 622 IPR027936

Functions

Description
EC Number 6.5.1.1 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA ligase (ATP) activity Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

6 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
DNA biosynthetic process The biosynthetic process resulting in the formation of DNA.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLFGELAQYF ERIEKTTKRN EMMEILADLF RKVDKEEIDK IIYLLNGRVA PDYEKIEFGM
70 80 90 100 110 120
SDKLVLRAMA LALKIPLLEL ERSYKEVGDL GELVVKYSKN EGKDLTVVET FNTLYDIANL
130 140 150 160 170 180
SGEGSVDAKV NRLAFLINSL TPQGGKYLVR IVLGKLRLGV GEPTIMDALS FAKVKDKGLR
190 200 210 220 230 240
PFIERAFNIT SDLGYVAKVF WEGGVEALKR IKVQVGRPIR MALAERVSRA EEIIKRLGKC
250 260 270 280 290 300
AVEPKFDGFR CQIHKKENSV RIFSRNLEDN TYMFPDLVEA VLKQFPDRDV IIEGEAISYN
310 320 330 340 350 360
PETGEFYPFQ VTVQRKRKYN ISEMVELYPL QLFAFDILYL DGEDTTSLPY IRRRQKLEEA
370 380 390 400 410 420
LVEGEKISIT KNIITNDPKE IQSFFEECIT EGLEGIVAKR LDAPYQAGMR NFNWIKLKRS
430 440 450 460 470 480
YQGHLADTVD CVILGYFKGR GHRAKFGIGA LLVGVYDDER DLFKTIAKIG TGPTEEEWVK
490 500 510 520 530 540
FREILDEIKV EKRPNNVESF IEPDVWVEPK YVVVVQADEI TRSPVHTCGR ELDGLGYALR
550 560 570 580
FPRVQGFVRE DKGPYDATTV KEILEMFRNQ KKEKVEEDSD LL