B5Y1Z8

PR
Gene name
kefC
Protein name
Glutathione-regulated potassium-efflux system protein KefC
Names
K(+)/H(+) antiporter
Species
Klebsiella pneumoniae (strain 342)
KEGG Pathway
kpe:KPK_4698
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

554-621 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5Y1Z8

Entry ID Method Resolution Chain Position Source
AF-B5Y1Z8-F1 Predicted AlphaFoldDB

No variants for B5Y1Z8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5Y1Z8

No associated diseases with B5Y1Z8

5 regional properties for B5Y1Z8

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 156 - 495 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 63 - 140 IPR004365
domain Aminoacyl-tRNA synthetase, class II 178 - 493 IPR006195
domain Lysyl-tRNA synthetase, class II, C-terminal 171 - 496 IPR018149
domain Lysine-tRNA ligase, class II, N-terminal 62 - 168 IPR044136

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
glutathione-regulated potassium exporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state.
solute:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
toxic substance binding Binding to a toxic substance, a poisonous substance that causes damage to biological systems.

1 GO annotations of biological process

Name Definition
response to methylglyoxal Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSHTLIQAL IYLGAAALIV PIAVRLGLGS VLGYLIAGCI IGPWGLRLVT DAEAILHFAE
70 80 90 100 110 120
IGVVLMLFVI GLELDPQRLW KLRASVFGGG ALQMVACGVL IGLFCMLLGL RWQVAELIGM
130 140 150 160 170 180
TLALSSTAIA MQAMNERNLT VSQMGRSAFA VLLFQDIAAI PLVAMIPLLA ASGGATSLVA
190 200 210 220 230 240
FALSALKVAA ALALVVALGR YLTRPLLRFV ARSGLREVFS AVALFLVFGF GLLLEEVGLS
250 260 270 280 290 300
MAMGAFLAGV LLASSEYRHA LESDIEPFKG LLLGLFFIGV GMSIDFGTLV THPLRIVILL
310 320 330 340 350 360
VGFLAIKMLM LWLIARPLGV PRAQRRWFAV LLGQGSEFAF VVFGAARMAD VLDGEWAKAL
370 380 390 400 410 420
TLAVALSMAA TPVLLVLLTR LEKSASGQAR DADEIDEEQP RVIVAGFGRF GQIAGRLLLS
430 440 450 460 470 480
SGVKMVILDH DPDHVDTLRK FDMKVFYGDA TRVDLLESAG AEKAEVLINA IDDPHVSLEL
490 500 510 520 530 540
VERVKEHFPH LQIISRARDV DHYIKLRQAG VEAPERETFE AALKSGRMTL EALGLGAYEA
550 560 570 580 590 600
RERADLFRRF NLQMVEEMVA MAENDAASRV AVFKRTSDML TGIINEDRHH LSLVQRHGWQ
610 620
GTEEGRHTGD IADEPENKPS A