B5XML5

PR
Gene name
proA
Protein name
Gamma-glutamyl phosphate reductase
Names
GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase
Species
Streptococcus pyogenes serotype M49 (strain NZ131)
KEGG Pathway
soz:Spy49_1295c
EC number
1.2.1.41: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5XML5

Entry ID Method Resolution Chain Position Source
AF-B5XML5-F1 Predicted AlphaFoldDB

No variants for B5XML5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5XML5

No associated diseases with B5XML5

4 regional properties for B5XML5

Type Name Position InterPro Accession
domain GPR domain 3 - 415 IPR000965
domain Aldehyde dehydrogenase domain 36 - 283 IPR015590-1
domain Aldehyde dehydrogenase domain 301 - 378 IPR015590-2
conserved_site Gamma-glutamyl phosphate reductase GPR, conserved site 322 - 344 IPR020593

Functions

Description
EC Number 1.2.1.41 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
glutamate-5-semialdehyde dehydrogenase activity Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

1 GO annotations of biological process

Name Definition
L-proline biosynthetic process The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDMRRLGQR AKQASLLIAP LSTQIKNRFL STLAKALVDD TQTLLAANQK DLANAKEHGI
70 80 90 100 110 120
SDIMMDRLRL TSERIKAMAQ GVQQVADLAD PIGQVIKGYT NLDGLKILQK RVPLGVIAMI
130 140 150 160 170 180
FESRPNVSVD AFSLAFKTNN AIILRGGKDA LHSNKALVKL IRQSLEKSGI TPDAVQLVED
190 200 210 220 230 240
PSHAVAEELM QATDYVDVLI PRGGAKLIQT VKEKAKVPVI ETGVGNVHIY VDAQADLDMA
250 260 270 280 290 300
TKIVINAKTK RPSVCNAAEG LVIHEAVAAR FIPMLEKAIN QVQPVEWRAD DKALPLFEQA
310 320 330 340 350 360
VPAKAEDFET EFLDYIMSVK VVSSLEEAIF WINQHTSHHS EAIITRDIKV AETFQDLVDA
370 380 390 400 410
AAVYVNASTR FTDGFVFGLG AEIGISTQKM HARGPMGLEA LTSTKFYING DGHIRE