B5X3Z6

PR
Gene name
pafah1b1-1 (lis1-1)
Protein name
Lissencephaly-1 homolog A
Names
Species
Salmo salar (Atlantic salmon)
KEGG Pathway
sasa:100195354
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5X3Z6

Entry ID Method Resolution Chain Position Source
AF-B5X3Z6-F1 Predicted AlphaFoldDB

No variants for B5X3Z6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5X3Z6

No associated diseases with B5X3Z6

9 regional properties for B5X3Z6

Type Name Position InterPro Accession
repeat WD40 repeat 97 - 410 IPR001680
domain LIS1 homology motif 7 - 39 IPR006594
conserved_site WD40 repeat, conserved site 165 - 179 IPR019775-1
conserved_site WD40 repeat, conserved site 207 - 221 IPR019775-2
conserved_site WD40 repeat, conserved site 311 - 325 IPR019775-3
conserved_site WD40 repeat, conserved site 395 - 409 IPR019775-4
repeat G-protein beta WD-40 repeat 123 - 137 IPR020472-1
repeat G-protein beta WD-40 repeat 207 - 221 IPR020472-2
repeat G-protein beta WD-40 repeat 311 - 325 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Localizes to the plus end of microtubules and to the centrosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
1-alkyl-2-acetylglycerophosphocholine esterase complex An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF).
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule associated complex Any multimeric complex connected to a microtubule.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

2 GO annotations of molecular function

Name Definition
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

6 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
microtubule sliding The movement of one microtubule along another microtubule.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
reelin-mediated signaling pathway The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDMN EELDKKYAGL LEKKWTSVIR
70 80 90 100 110 120
LQKKVMELES KLNEAKEEIT LGGPIAQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF
130 140 150 160 170 180
SVMVSASEDA TIKVWDYETG DFERTLKGHT DSVQDISFDH TGKLLASCSA DMTIKLWDFQ
190 200 210 220 230 240
GFECIRTMHG HDHNVSSVAI MPNGDHIVSA SRDKTIKMWE VATGYCVKTF TGHREWVRMV
250 260 270 280 290 300
RPNQDGTLIA SCSNDQTVRV WVVASKECKA ELREHEHVVE CISWAPESAH PTILEATGSE
310 320 330 340 350 360
SKKSGKPGPF LLSGSRDKTI KMWDVSIGMC LMTLVGHDNW VRGMLVHPGG KFILSCADDK
370 380 390 400
TLRIWDYKNK RCMKTLGAHE HFVTSLDFHK NAPYVVTGSV DQTVKVWECR