B5UAQ8

PR
Gene name
CYP719A5
Protein name
Cheilanthifoline synthase
Names
CHS, Cytochrome P450 719A5
Species
Eschscholzia californica (California poppy)
KEGG Pathway
EC number
1.14.19.65: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5UAQ8

Entry ID Method Resolution Chain Position Source
AF-B5UAQ8-F1 Predicted AlphaFoldDB

No variants for B5UAQ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5UAQ8

No associated diseases with B5UAQ8

1 regional properties for B5UAQ8

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 425 - 434 IPR017972

Functions

Description
EC Number 1.14.19.65 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
(S)-cheilanthifoline synthase activity Catalysis of the reaction: (S)-scoulerine + + O2 -> (S)-cheilanthifoline
heme binding +Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.

1 GO annotations of biological process

Name Definition
isoquinoline alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEESLWVVTA TVVVVFAIAK LLKKSSSIST MEWPKGPKKL PIIGNLHQLG GEAFHVVLAN
70 80 90 100 110 120
LAKIHGTVMT IWVGAWRPMI VISDIDKAWE VLVNKSSDYA GRDFPEITKI ISANWKNISC
130 140 150 160 170 180
SDSGPFWQNL RKGLQGGALA PLNVISQYQL QERDMKNLIT SMQEKASKNN GILKPLDYLK
190 200 210 220 230 240
EETIRLLSRL IFGQSFNDEN FVKGVHLALD DLVRISGYAS LADAFKFCEN LPSHKKSIRE
250 260 270 280 290 300
VHEVNERVVN LVKPYLVKNP PTNTYLYFLN SQKFSDEVII SAVLEVYDLG VDSTASTAVW
310 320 330 340 350 360
ALTFLVREPR VQEKLYKEII DLTGGERSVK VEDVSKLPYL QAVMKETMRM KPIAPMAIPH
370 380 390 400 410 420
KTSRDTSLMG KKVNKGTSIM VNLYAIHHNP KVFPEPYKFI PERFLQGQES KYGDIKEMEQ
430 440 450 460 470 480
SLLPFSAGMR ICAGMELGKL QYGFSLASLV EAFKWTCAVD GKLPDLSEDH CFILLMKNPL
EARITPRTQL