B5R6F7

PR
Gene name
hpcH
Protein name
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Names
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase
Species
Salmonella gallinarum (strain 287/91 / NCTC 13346)
KEGG Pathway
seg:SG0995
EC number
4.1.2.52: Aldehyde-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

217-263 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5R6F7

Entry ID Method Resolution Chain Position Source
AF-B5R6F7-F1 Predicted AlphaFoldDB

No variants for B5R6F7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5R6F7

No associated diseases with B5R6F7

2 regional properties for B5R6F7

Type Name Position InterPro Accession
domain AAA+ ATPase domain 122 - 278 IPR003593
domain Stage III sporulation protein AA, AAA+ ATPase domain 121 - 253 IPR045735

Functions

Description
EC Number 4.1.2.52 Aldehyde-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde.
4-hydroxy-2-ketopimelate aldolase activity Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
phenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylacetate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNAFKDALK AGRPQIGLWL GLANSYSAEL LAGAGFDWLL IDGEHAPNNV QTVLTQLQAI
70 80 90 100 110 120
APYPSQPVVR PSWNDPVQIK QLLDVGAQTL LIPMVQNADE ARNAVAATRY PPAGIRGVGS
130 140 150 160 170 180
ALARASRWNR IPDYLHQAND AMCVLVQIET REAMSNLASI LDVDGIDGVF IGPADLSADM
190 200 210 220 230 240
GFAGNPQHPE VQAAIENAIV QIRAAGKAPG ILMANEALAK RYLELGALFV AVGVDTTLLA
250 260
RGAEALAARF GAEKKLSGAS GVY