B5EEZ1

PR
Gene name
hldE
Protein name
Bifunctional protein HldE
Names
Species
Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem) (Geobacter bemidjiensis)
KEGG Pathway
gbm:Gbem_0864
EC number
2.7.1.167: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

73-160 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5EEZ1

Entry ID Method Resolution Chain Position Source
AF-B5EEZ1-F1 Predicted AlphaFoldDB

No variants for B5EEZ1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5EEZ1

No associated diseases with B5EEZ1

4 regional properties for B5EEZ1

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 354 - 447 IPR004821
domain Carbohydrate kinase PfkB 19 - 316 IPR011611
domain RfaE bifunctional protein, domain I 11 - 321 IPR011913
domain RfaE bifunctional protein, domain II 345 - 484 IPR011914

Functions

Description
EC Number 2.7.1.167 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
heptose 7-phosphate kinase activity Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP.
heptose-1-phosphate adenylyltransferase activity Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose.
phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

1 GO annotations of biological process

Name Definition
ADP-L-glycero-beta-D-manno-heptose biosynthetic process The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERREVESFF ERATSIRALV VGDLMLDEYL WGRAERISPE APVQVVEVAR EDLRLGGAGN
70 80 90 100 110 120
VVNNLAALGC QVSVCSVIGS DENGALLRRA LEEKGAGLEG LFEEGERRTS KKTRVLAANQ
130 140 150 160 170 180
QIVRIDRETK SSIAAASEQG IIDYLAARSG DFDVIVVSDY LKGVLTPAVL SAVCRSGREL
190 200 210 220 230 240
GIPVVVDPKG NDYGKYRGAT ILTPNRKEAE IASGVAITDQ ESLQCAASGL LSCLELDALL
250 260 270 280 290 300
ITRSEAGMSL FPAAGGAVHI PTVAREVFDV TGAGDTVISV LSLGLACGLT MADAAWIANV
310 320 330 340 350 360
AAGIAVGKLG TSTVAPQEIV AEVGHGAKDS DSKIKNLDVL AHAIAREHSR GKKVVFTNGC
370 380 390 400 410 420
FDLLHVGHVK YLQKARGLGD ILVVGLNTDA SVRRLKGEKR PLIEETERAH ILAALDCIDY
430 440 450 460 470 480
VVLFDEDTPL KVIETLGPDI LVKGGDYSIE GVVGREVVEA RGGRVELIQF VDGRSTSRII
EKILSSY