B5BT18
PR
Gene name |
BTAF1 (RGD3, At3g54280, F24B22.240) |
Protein name |
TATA-binding protein-associated factor BTAF1 |
Names |
AtBTAF1, Protein BTAF1 homolog, Protein ROOT GROWTH DEFECTIVE 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G54280 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B5BT18
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B5BT18-F1 | Predicted | AlphaFoldDB |
99 variants for B5BT18
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12754907 | 10 | N>D | No | 1000Genomes | |
| tmp_3_20092606_C_A | 41 | Q>K | No | 1000Genomes | |
| ENSVATH00418847 | 86 | N>I | No | 1000Genomes | |
| tmp_3_20093582_C_T | 90 | T>M | No | 1000Genomes | |
| ENSVATH06313059 | 92 | L>F | No | 1000Genomes | |
| ENSVATH06313060 | 93 | G>C | No | 1000Genomes | |
| ENSVATH06313060 | 93 | G>S | No | 1000Genomes | |
| tmp_3_20093652_G_T | 113 | K>N | No | 1000Genomes | |
| tmp_3_20093663_A_G | 117 | N>S | No | 1000Genomes | |
| ENSVATH00418848 | 120 | F>V | No | 1000Genomes | |
| tmp_3_20094558_G_A | 164 | R>Q | No | 1000Genomes | |
| ENSVATH14432600 | 165 | R>Q | No | 1000Genomes | |
| ENSVATH06313075 | 182 | I>V | No | 1000Genomes | |
| tmp_3_20094919_A_G | 193 | N>S | No | 1000Genomes | |
| tmp_3_20094984_T_C | 215 | F>L | No | 1000Genomes | |
| ENSVATH12755024 | 251 | S>C | No | 1000Genomes | |
| ENSVATH06313077 | 259 | M>K | No | 1000Genomes | |
| ENSVATH00418858 | 261 | S>L | No | 1000Genomes | |
| tmp_3_20095729_C_T | 314 | A>V | No | 1000Genomes | |
| tmp_3_20095795_C_G | 336 | A>G | No | 1000Genomes | |
| tmp_3_20095838_G_C | 350 | E>D | No | 1000Genomes | |
| tmp_3_20095881_G_A | 365 | D>N | No | 1000Genomes | |
| tmp_3_20095924_G_A | 379 | R>Q | No | 1000Genomes | |
| tmp_3_20095967_T_G | 393 | D>E | No | 1000Genomes | |
| ENSVATH12755085 | 394 | N>Y | No | 1000Genomes | |
| ENSVATH12755086 | 396 | V>I | No | 1000Genomes | |
| tmp_3_20095987_T_C | 400 | I>T | No | 1000Genomes | |
| ENSVATH06313086 | 411 | E>K | No | 1000Genomes | |
| ENSVATH12755087 | 426 | T>S | No | 1000Genomes | |
| ENSVATH06313087 | 434 | E>A | No | 1000Genomes | |
| ENSVATH00418860 | 440 | D>E | No | 1000Genomes | |
| tmp_3_20096116_C_T | 443 | T>I | No | 1000Genomes | |
| ENSVATH06313088 | 449 | N>S | No | 1000Genomes | |
| ENSVATH00418861 | 451 | V>M | No | 1000Genomes | |
| tmp_3_20096170_A_C | 461 | K>T | No | 1000Genomes | |
| ENSVATH14432626 | 465 | E>K | No | 1000Genomes | |
| tmp_3_20096205_C_G | 473 | Q>E | No | 1000Genomes | |
| ENSVATH12755089 | 481 | D>N | No | 1000Genomes | |
| tmp_3_20096598_A_G | 554 | Q>R | No | 1000Genomes | |
| tmp_3_20097114_G_T | 608 | A>S | No | 1000Genomes | |
| tmp_3_20097167_G_T | 625 | Q>H | No | 1000Genomes | |
| tmp_3_20097169_C_T | 626 | T>I | No | 1000Genomes | |
| tmp_3_20097448_G_A | 681 | E>K | No | 1000Genomes | |
| tmp_3_20097463_G_C | 686 | G>R | No | 1000Genomes | |
| ENSVATH06313100 | 687 | H>R | No | 1000Genomes | |
| ENSVATH12755120 | 690 | S>R | No | 1000Genomes | |
| ENSVATH12755121 | 697 | V>I | No | 1000Genomes | |
| tmp_3_20097501_G_T | 698 | K>N | No | 1000Genomes | |
| ENSVATH00418866 | 700 | S>I | No | 1000Genomes | |
| ENSVATH06313101 | 719 | I>L | No | 1000Genomes | |
| ENSVATH06313107 | 792 | D>N | No | 1000Genomes | |
| tmp_3_20098204_C_G | 810 | A>G | No | 1000Genomes | |
| ENSVATH06313109 | 860 | S>T | No | 1000Genomes | |
| tmp_3_20098369_A_C | 865 | E>A | No | 1000Genomes | |
| ENSVATH12755160 | 883 | M>T | No | 1000Genomes | |
| ENSVATH06313110 | 885 | M>I | No | 1000Genomes | |
| ENSVATH06313111 | 889 | R>H | No | 1000Genomes | |
| ENSVATH06313112 | 906 | R>Q | No | 1000Genomes | |
| ENSVATH06313114 | 937 | I>V | No | 1000Genomes | |
| ENSVATH12755162 | 947 | A>T | No | 1000Genomes | |
| ENSVATH06313115 | 952 | S>I | No | 1000Genomes | |
| ENSVATH02503466 | 960 | S>G | No | 1000Genomes | |
| tmp_3_20098876_A_T | 1005 | H>L | No | 1000Genomes | |
| ENSVATH06313117 | 1005 | H>Y | No | 1000Genomes | |
| ENSVATH06313119 | 1018 | S>T | No | 1000Genomes | |
| ENSVATH02503467 | 1031 | E>D | No | 1000Genomes | |
| tmp_3_20098968_G_A | 1036 | A>T | No | 1000Genomes | |
| ENSVATH06313120 | 1043 | N>S | No | 1000Genomes | |
| tmp_3_20099008_A_T | 1049 | N>I | No | 1000Genomes | |
| tmp_3_20099472_A_G | 1134 | I>V | No | 1000Genomes | |
| tmp_3_20099484_G_A | 1138 | V>I | No | 1000Genomes | |
| tmp_3_20099568_G_A | 1166 | A>T | No | 1000Genomes | |
| tmp_3_20099632_C_T | 1187 | T>I | No | 1000Genomes | |
| ENSVATH06313122 | 1192 | A>S | No | 1000Genomes | |
| ENSVATH06313123 | 1197 | A>V | No | 1000Genomes | |
| ENSVATH06313124 | 1224 | K>N | No | 1000Genomes | |
| tmp_3_20099802_C_T | 1244 | L>F | No | 1000Genomes | |
| tmp_3_20099856_A_G | 1262 | I>V | No | 1000Genomes | |
| ENSVATH12755230 | 1280 | P>L | No | 1000Genomes | |
| tmp_3_20100156_G_C | 1319 | M>I | No | 1000Genomes | |
| tmp_3_20100418_C_T | 1407 | R>C | No | 1000Genomes | |
| ENSVATH12755260 | 1504 | L>P | No | 1000Genomes | |
| tmp_3_20101119_G_T | 1522 | A>S | No | 1000Genomes | |
| tmp_3_20101161_G_A | 1536 | V>M | No | 1000Genomes | |
| tmp_3_20101294_A_T | 1580 | Y>F | No | 1000Genomes | |
| tmp_3_20101767_C_T | 1664 | A>V | No | 1000Genomes | |
| ENSVATH06313143 | 1684 | T>M | No | 1000Genomes | |
| tmp_3_20102049_A_T | 1724 | I>L | No | 1000Genomes | |
| ENSVATH06313145 | 1736 | S>T | No | 1000Genomes | |
| tmp_3_20102316_C_A | 1781 | A>E | No | 1000Genomes | |
| ENSVATH06313148 | 1782 | A>T | No | 1000Genomes | |
| tmp_3_20102436_G_C | 1821 | S>T | No | 1000Genomes | |
| tmp_3_20102637_C_T | 1853 | A>V | No | 1000Genomes | |
| tmp_3_20103122_G_A | 1905 | D>N | No | 1000Genomes | |
| tmp_3_20103451_A_C | 1955 | K>T | No | 1000Genomes | |
| ENSVATH02503487 | 1995 | G>A | No | 1000Genomes | |
| ENSVATH02503488 | 2000 | G>V | No | 1000Genomes | |
| ENSVATH12755341 | 2022 | E>K | No | 1000Genomes | |
| tmp_3_20103763_G_A | 2032 | E>K | No | 1000Genomes |
No associated diseases with B5BT18
No regional properties for B5BT18
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for B5BT18 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent activity, acting on DNA | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| TBP-class protein binding | Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of shoot apical meristem development | Any process that activates or increases the frequency, rate or extent of shoot apical meristem development. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O14981 | BTAF1 | TATA-binding protein-associated factor 172 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQQQSSRLN | RLLTLLDTGS | TQATRLTAAK | QIGDIAKSHP | QDLSSLLRKV | LHHLRSKKWD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TRVAAAHAIG | AIVLNVKHPS | LSELLNSLAT | KLGEAGISDN | VDEVVAFRNL | QSKILANAPF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSFEMNKVLE | FGALLASGGQ | EYDILNDNSK | NPRDRVARQK | KNLRRRLGLD | MCEQFMDVNE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MIRDEDLIEQ | KSNVPANGVG | NRLYANCSPH | HIQQFVSRMV | PRVNSRRPSA | RELNLLKRKA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KISSKDQAKG | SCEVADVEMS | SSHVASTSKR | ILSDSLDSSK | ADIGNEDDIE | PDGDGKWPFH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SFVEQLILDM | FDPAWEIRHG | SVMALREILM | LHGGSAGVST | EEFSSDNGFE | LKDVLNKVTR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EREIDLNMQV | SENELEPLRK | RPKIEDPSKS | FIDNTVLEVI | GGDYDINVKD | EDAEFLLPPV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KVNGQTDCSS | TKLEPQSSMD | DSTSHSEINH | VAEVNNHFED | KSFIEEPVIP | KQQEENLEVL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLVKQARHSW | IKNFEFLQDC | TIRFLCVLSL | DRFGDYISDQ | VVAPVREACA | QALGATFKYM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NPSLIYETLN | ILLQMQRRPE | WEIRHGSLLG | IKYLVAVRQE | MLQDLLGYIL | PACKAGLEDS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DDDVRAVAAD | ALIPAAAAIV | SLRGQTLLSI | VMLLWDILLE | LDDLSPSTSS | IMNLLAEIYS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QDDMTLVMHE | ELSLGEEQNI | ELNEMGHIES | IGERRDVKES | PYALSGLAPR | LWPFTRHDIT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SVRFSAIRTL | ERLLEAGCRK | NISGQSKSSF | WPSSILGDTL | RIVFQNLLLE | STEEILECSE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RVWRLLVQCP | VDDLEDTAKF | YMASWIELAA | TPYGSTLDAT | KMFWPVAPPR | KSHFKAAAKM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KAVKLENEAS | SILGFDYARS | SASLEKQEDA | SARSTKIIVG | SDMEMSVTRT | RVVTASALGI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| FASRLREGSM | QFVVDPLSST | LTSMSGVQRQ | VGSIVLISWF | RETKCKAPSD | GSGSLPGFPS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PLKKWLLDLL | ACADPAFPTK | DIFLPYAELS | RTYTKMRNEA | SQLLHTVETC | HCFDKLLSTN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KLNVESVTAD | ETIDFASTLD | LWNKESAGNE | SLEKQVFEDV | ESSRQQLLST | AGYLKCVQSN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LHITVTSLVA | AAVVWMSEFP | ARLNPIILPL | MASIKREQEQ | ILQQIAAEAL | AELIAYCVDR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KPSPNDKLIK | NICSLTCMDP | SETPQASIIS | SMDIVDDMDF | LSSRSNTGKQ | KAKVVLASGE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| DRSKVEGFIT | RRGSELALKH | LSLKFGGSLF | DKLPKLWECL | TEVLVPEIPS | DQQKIDLKIE |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| SISDPQVLIN | NIQVVRSIAP | VMEETLKPRL | LSLLPCIFKC | VRHSHVAVRL | AASRCVMTMA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KSMTTDVMAA | VVESAIPMLG | DLTCISGRQG | AGMLIGLLVQ | GLGVELVPYS | PLLVVPLLRC |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| MSDVDSSVRQ | SVTRSFAALV | PMLPLARGVP | PPVGLSKDLS | SNAEDAKFLE | QLLDNSHIDD |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| YKLCTELKVQ | LRRYQQEGIN | WLGFLKRFKL | HGILCDDMGL | GKTLQASAIV | ASDAAERRGS |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| TDELDVFPSI | IVCPSTLVGH | WAFEIEKYID | LSLLSVLQYV | GSAQDRVSLR | EQFNNHNVII |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| TSYDVVRKDV | DYLTQFSWNY | CILDEGHIIK | NAKSKITAAV | KQLKAQHRLI | LSGTPIQNNI |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| MELWSLFDFL | MPGFLGTERQ | FQASYGKPLL | AARDPKCSAK | DAEAGVLAME | ALHKQVMPFL |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| LRRTKEEVLS | DLPEKIIQDR | YCDLSPVQLK | LYEQFSGSSA | KQEISSIIKV | DGSADSGNAD |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| VAPTKASTHV | FQALQYLLKL | CSHPLLVLGD | KVTEPVASDL | AAMINGCSDI | ITELHKVQHS |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| PKLVALQEIL | EECGIGSDAS | SSDGTLSVGQ | HRVLIFAQHK | ALLDIIEKDL | FQAHMKSVTY |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| MRLDGSVVPE | KRFEIVKAFN | SDPTIDVLLL | TTHVGGLGLN | LTSADTLVFM | EHDWNPMRDH |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| QAMDRAHRLG | QKRVVNVHRL | IMRGTLEEKV | MSLQKFKVSV | ANTVINAENA | SMKTMNTDQL |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| LDLFASAETS | KKGGGSSKKG | SEDNDQIAGT | GKGMKAILGN | LEELWDQSQY | TEEYNLSQFL |
| TKLNG |