B4SY26

PR
Gene name
folE
Protein name
GTP cyclohydrolase 1
Names
GTP cyclohydrolase I, GTP-CH-I
Species
Salmonella newport (strain SL254)
KEGG Pathway
see:SNSL254_A2384
EC number
3.5.4.16: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4SY26

Entry ID Method Resolution Chain Position Source
AF-B4SY26-F1 Predicted AlphaFoldDB

No variants for B4SY26

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4SY26

No associated diseases with B4SY26

3 regional properties for B4SY26

Type Name Position InterPro Accession
conserved_site GTP cyclohydrolase I, conserved site 98 - 114 IPR018234-1
conserved_site GTP cyclohydrolase I, conserved site 146 - 156 IPR018234-2
domain GTP cyclohydrolase I domain 41 - 218 IPR020602

Functions

Description
EC Number 3.5.4.16 In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
7,8-dihydroneopterin 3'-triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSLSKEAAL VHDALVARGL ETPLRPPMDE LDNETRKSLI AGHMTEIMQL LNLDLSDDSL
70 80 90 100 110 120
METPHRIAKM YVDEIFAGLD YANFPKITLI ENKMKVDEMV TVRDITLTST CEHHFVTIDG
130 140 150 160 170 180
KATVAYIPKD SVIGLSKINR IVQFFAQRPQ VQERLTQQIL TALQTLLGTN NVAVSIDAVH
190 200 210 220
YCVKARGIRD ATSATTTTSL GGLFKSSQNT RQEFLRAVRH HP