B4NDG5
PR
Gene name |
GK24923 |
Protein name |
Regulator of telomere elongation helicase 1 homolog |
Names |
|
Species |
Drosophila willistoni (Fruit fly) |
KEGG Pathway |
|
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B4NDG5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B4NDG5-F1 | Predicted | AlphaFoldDB |
No variants for B4NDG5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B4NDG5 | |||||
No associated diseases with B4NDG5
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| metal ion binding | Binding to a metal ion. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| male germ-line stem cell population maintenance | The process by which an organism or tissue maintains a population of male germ-line stem cells. |
| negative regulation of response to DNA damage stimulus | Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. |
| regulation of double-strand break repair via homologous recombination | Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPESIIAGIP | VHFPFEPYEV | QRAFMEKVII | CLRDGTNGVL | ESPTGTGKTL | SLLCSSLAWI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTRQSEQQKQ | IRKLQDAANN | TKVGPTGIVP | GEAAELALTV | GKANNWGVPK | VIYASRTHSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LTQAMRELKR | SAYAGMRSVV | LGSRDQLCIH | PEVMREQGNS | NKVNMCKMRV | HSKTCSFQLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VESKKDHPDF | RGPSIMDIED | LVKVGQKLKM | CPYFASKELV | NDADITFMPY | NYLLDPMARK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ANKIELSNTI | VILDEAHNIE | KICEESASVQ | IKSSDVAVAI | EDVTHIMRIF | TSADSQDFSG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DEPKDFTLDD | LTLLKEMLLE | LEKAIDGVVV | DNLAEGTTYP | ASYMYELLAK | ANFTYGNCAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IVALLDKLVQ | YLMVASQNNS | SMIMRKGGSF | LVLAELLTIV | FANKEDIMAK | VHRSFKVHVE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VEEAKQNAGK | PAPKQQQQGG | WLGKGNNTSN | SSSSNKAKVI | NFWCFNPGFG | MEQLLNTQVR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SVILTSGTLA | PLKPLIAELA | IPVAQHLENP | HIVDQSQVYV | KIIGTGPDRQ | QLISNFKNRD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NPKYISSLGQ | TILNVSRIVP | DGLLVFFPSY | PMLNKCVDAW | QTSGLWADIA | AKKPIFLEPR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GKDQFTTTME | EFYQAIRDSK | GACFMAVCRG | KVSEGLDFAD | RNGRAVIITG | LPYPPLKDPK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VILKRRYLEA | NRTKENQLLT | GQEWYNLDAT | RAVNQAIGRV | IRHRHDYGAI | LLCDSRFQDN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SQVQQLSKWI | RGHLGARPQC | SPFGPIVREL | RQFFRHAEET | MEQPKERTDE | PLLKNVYKTE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AVTQENNEEK | PLFKVKREPG | QMATNAAAFK | QANEMAIKVE | MTNSIKSWTP | DDYVSAAGRT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QSHSQSKPPN | AMDFMSRLDS | NVSSIDFNST | GTGNLVKIHK | RERSSPTFGD | TKSSSQLKKR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YKLVDNIKTE | PSTSSSCKAP | ESRADFLREV | RCFINQDEFR | DFGKALLAYK | NGGDEAFESL |
| 970 | 980 | 990 | |||
| MSLLFKLLGK | PQMRYLLLGI | RRYLKNEHKA | EFDKRVAT |