B4N7R4

PR
Gene name
Uba4
Protein name
Adenylyltransferase and sulfurtransferase MOCS3
Names
Molybdenum cofactor synthesis protein 3, Ubiquitin activating enzyme 4
Species
Drosophila willistoni (Fruit fly)
KEGG Pathway
dwi:6646750
EC number
2.7.7.80: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4N7R4

Entry ID Method Resolution Chain Position Source
AF-B4N7R4-F1 Predicted AlphaFoldDB

No variants for B4N7R4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4N7R4

No associated diseases with B4N7R4

2 regional properties for B4N7R4

Type Name Position InterPro Accession
domain THIF-type NAD/FAD binding fold 73 - 311 IPR000594
domain Rhodanese-like domain 348 - 455 IPR001763

Functions

Description
EC Number 2.7.7.80 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
molybdopterin-synthase adenylyltransferase activity Catalysis of the reaction: ATP
molybdopterin-synthase sulfurtransferase activity Catalysis of the reaction: -Gly-NH-CH(2)-C(O)SH + cysteine desulfurase.
thiosulfate sulfurtransferase activity Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate.
ubiquitin-like modifier activating enzyme activity Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.

2 GO annotations of biological process

Name Definition
Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
tRNA wobble position uridine thiolation The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLGVEALRNE RSRLRQEIAD LRSAICKKEQ SLRELEEALA NGGGNGDGLA DEGGERNTGT
70 80 90 100 110 120
IQTQLTNDDI ARYSRQLILP NFGVQGQLRL KNSSVLIVGM GGLGCPAAQY LAAAGVGYLG
130 140 150 160 170 180
LIDYDQVERS NFHRQTLHTE ARCGMAKTES ARIALLELNP SCRIHCHSEL INSHNASNIM
190 200 210 220 230 240
RSYDVVLDCS DNVATRYLLN DACVIFRKPL VSGSALKMDG QLTVYNYGAQ GPCYRCIYPV
250 260 270 280 290 300
PPPPEAVTNC GDGGVLGAVT GVIGSLQALE TIKIIVGGLG EVLAGRMLIF DGTTGQFRNI
310 320 330 340 350 360
RIRSKRSNCH ACSSQPLITD LIDYELFCGM HATDKDHPLQ LLESDQRLDV QTYHDKLESQ
370 380 390 400 410 420
PHLLFDVRST AEFEICQLST NAINLPLAEV LDDSYLKRFA VELQNKDLPI IVLCRRGNDS
430 440 450
QIAVQHMRNR FPDHSIRDLI GGLHAWTRKV DPDFPIY