B4JW98
Gene name |
calypso (GH22997) |
Protein name |
Ubiquitin carboxyl-terminal hydrolase calypso |
Names |
BAP1 homolog |
Species |
Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
KEGG Pathway |
dgr:6568805 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B4JW98
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B4JW98-F1 | Predicted | AlphaFoldDB |
No variants for B4JW98
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B4JW98 | |||||
No associated diseases with B4JW98
15 regional properties for B4JW98
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | 203 - 387 | IPR005479-1 |
| domain | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | 738 - 801 | IPR005479-2 |
| domain | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | 828 - 961 | IPR005479-3 |
| domain | Carbamoyl-phosphate synthetase, large subunit oligomerisation domain | 480 - 602 | IPR005480 |
| domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | 631 - 645 | IPR005483-1 |
| domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | 660 - 670 | IPR005483-2 |
| domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | 778 - 790 | IPR005483-3 |
| domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | 835 - 854 | IPR005483-4 |
| domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | 869 - 886 | IPR005483-5 |
| domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | 924 - 953 | IPR005483-6 |
| domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | 1003 - 1021 | IPR005483-7 |
| domain | Methylglyoxal synthase-like domain | 1027 - 1163 | IPR011607 |
| domain | ATP-grasp fold | 185 - 381 | IPR011761-1 |
| domain | ATP-grasp fold | 743 - 955 | IPR011761-2 |
| domain | Carbamoyl-phosphate synthase large chain, methylglyoxal synthase-like domain | 1033 - 1134 | IPR033937 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| PR-DUB complex | A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| heterochromatin assembly | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| monoubiquitinated histone H2A deubiquitination | The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. |
| specification of segmental identity, abdomen | The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVAGGSIST | AAGNAGKNNA | LPMAQLADGW | LELESDPGLF | TLLLEDFGCH | DVQVEEVYDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QKPIESPYGF | IFLFRWIEER | RARRKIVETT | AEIFVKDEEA | ISSIFFAQQV | VPNSCATHAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSVLLNCNEN | NLQLGETLGR | LKAHTKGMSP | ENKGLAIGNT | PELACAHNSH | AMPQARRRLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RTGAGVASCR | FTGEAFHFVS | FVPINGQLFE | LDGLKPYPMN | HGCWEEHEDW | TDKFRRVMAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLGIATGEQD | IRFNLMAVVP | DRRIAITHKL | KMLRTNQAIV | SGTLQKLLKA | DEQGERDEQQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RPDTPTTLLE | PSAFTARDLQ | SLLKNLDTEI | AINEQHLADE | NDRRQMFKVD | ASRRTHNYDK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FICTFLSMLA | HQGVLGELVS | QHLLPSKKIA | NRLNRQTNAA | TAAANAANTN | VAGTNAAGSK |
| 430 | 440 | 450 | 460 | ||
| SQQQQQQTQQ | QPQQTQTAKN | GKSPGKTPGR | RRKGRNKCRK | RK |