B4IUG3

PR
Gene name
Las1
Protein name
Lipoyl synthase 1, mitochondrial
Names
Lipoate synthase 1, LS 1, Lip-syn 1, Lipoic acid synthase 1
Species
Drosophila yakuba (Fruit fly)
KEGG Pathway
dya:Dyak_GE22745
EC number
2.8.1.8: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4IUG3

Entry ID Method Resolution Chain Position Source
AF-B4IUG3-F1 Predicted AlphaFoldDB

No variants for B4IUG3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4IUG3

No associated diseases with B4IUG3

3 regional properties for B4IUG3

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 127 - 333 IPR006638
domain Radical SAM 65 - 361 IPR007197
domain Lipoyl synthase, N-terminal 6 - 111 IPR031691

Functions

Description
EC Number 2.8.1.8 Sulfurtransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFGMLRALKT HVEAPIVVAT RAASTNAEKL EEIRERLAKG PNFQDFVQNP DNSRSEWENY
70 80 90 100 110 120
EGKLRREKGE EQRLRLPPWL KTTIPVGKNY AKIKAQMREL KLSTVCEEAR CPNIGECWGG
130 140 150 160 170 180
GEHGTQTATI MLMGDTCTRG CRFCSVKTAR KPPPLDVNEP VNTATAIASW GLDYIVLTSV
190 200 210 220 230 240
DRDDLPDGGS KHIAETVREI KARNSNIFVE CLVPDFRGNL ECVETIANSG LDVYAHNIET
250 260 270 280 290 300
VEKLTPYVRD RRAHYRQTLQ VLTEAKRFNP NLITKSSIML GLGETDEEIE STLKDLRTAG
310 320 330 340 350 360
VDCVTLGQYM QPTNKHLKVI EYVTPEKFKH WEERGNELGF LYTASGPLVR SSYKAGEFFI
370
TSILENRKKR QNATELSKE