B4IT27

PR
Gene name
GE16371
Protein name
Serine/threonine-protein kinase GE16371
Names
Doublecortin-like and CAM kinase-like protein
Species
Drosophila yakuba (Fruit fly)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

372-492 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4IT27

Entry ID Method Resolution Chain Position Source
AF-B4IT27-F1 Predicted AlphaFoldDB

No variants for B4IT27

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4IT27

No associated diseases with B4IT27

5 regional properties for B4IT27

Type Name Position InterPro Accession
domain Protein kinase domain 479 - 737 IPR000719
domain Doublecortin domain 154 - 245 IPR003533-1
domain Doublecortin domain 310 - 398 IPR003533-2
active_site Serine/threonine-protein kinase, active site 596 - 608 IPR008271
binding_site Protein kinase, ATP binding site 485 - 508 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELDKVKTHS LHCNAAVLSS LQAPTSATSP QSFTSKANAV AEAAFIENSN QQQNVQKDLN
70 80 90 100 110 120
SHNRDCDSPV SSTSELEKEF DDLRKLHTSS LTNSVVVGKS TGSLNGDYSI TSATSKTKTL
130 140 150 160 170 180
ESVVTINSAT GSACLTIAST ADHIKKRIPN SRTPTRKALR IKFYRNGDRF YPGVTIPVSN
190 200 210 220 230 240
ERYRSFERLF EDLTRLLEEN VKIPGAVRTI YNMCGKKITS LDELEDGQSY VCSCNNENFK
250 260 270 280 290 300
KVEYNPGSQP LSNLTLTNNS RPYNQRLAKH RPASPLKNGL LVGSSPLAVC GGGTGNGSPL
310 320 330 340 350 360
IASKSSDRVT VVHPRIVTLI RSGTKPRRIM RLLLNKRNSP SFDHVLTAIT QVVRLDTGYV
370 380 390 400 410 420
RKVFTLSGIS VVQLSDFFES DDVFFAYGTE RINTAEDFKL EPEELKAINV IRKTMRTAGT
430 440 450 460 470 480
TCKGPKPKMP IKSKKVYPPS VNSEAFKAAT APEDDRHATL LTSTGIEINE LPSNIRSTYT
490 500 510 520 530 540
LGKIIGDGNF AIVFKIKHRQ TGDSYALKII DKNKCKGKEH YIDAEVRVMK KLNHPHIISL
550 560 570 580 590 600
ILSVDQNTNM YLVLEYVSGG DLFDAITQVT RFAESQSRIM IRHLGAAMTY LHSMGIVHRD
610 620 630 640 650 660
IKPENLLVKL DEHGNVLELK LADFGLACEV NDLLYAVCGT PTYVAPEILL EVGYGLKIDV
670 680 690 700 710 720
WAAGIILYIL LCGFPPFVAP DNQQEPLFDA IISGIYEFPD PYWSDIGDGV RDLIANMLQS
730 740
DPDVRFTSED ILDHYWTIGN EGNECTTYKR