B4I298
Gene name |
WRNexo |
Protein name |
3'-5' exonuclease |
Names |
Werner Syndrome-like exonuclease |
Species |
Drosophila sechellia (Fruit fly) |
KEGG Pathway |
dse:6613768 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B4I298
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B4I298-F1 | Predicted | AlphaFoldDB |
No variants for B4I298
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B4I298 | |||||
No associated diseases with B4I298
6 regional properties for B4I298
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 161 - 200 | IPR001680-1 |
| repeat | WD40 repeat | 334 - 426 | IPR001680-2 |
| repeat | WD40 repeat | 462 - 567 | IPR001680-3 |
| repeat | WD40 repeat | 608 - 647 | IPR001680-4 |
| repeat | WD40 repeat | 840 - 880 | IPR001680-5 |
| conserved_site | WD40 repeat, conserved site | 361 - 375 | IPR019775 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| metal ion binding | Binding to a metal ion. |
| nucleic acid binding | Binding to a nucleic acid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of mitotic recombination | Any process that inhibits or decreases the rate of DNA recombination during mitosis. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERYLTKMPI | KSKANEVPKK | EAFAKKETPK | VARKATKTDT | PKELKDKENA | GDDNTPKQTK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRPGRPAAKR | KNLDTPDVKD | EKIAMEEENP | PKRRSSRLTR | STRSMAEDGS | PSPEKEKPEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPFIKYKGAI | KYFTESQDIA | ASADDVLQWV | EKQKDDVVPM | AFDMEWPFSF | QTGPGKSSVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QICVDEKCCY | IYQLTNVKKL | PAALVALINH | PKVRLHGVNI | KNDFRKLARD | FPEVTAEPLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EKCVDLGLWC | NEVCETGGRW | SLERLTNFIA | KKAMDKSKKV | RMSKWHVIPL | DENQLMYAAI |
| 310 | 320 | 330 | 340 | 350 | |
| DVYIGQVIYR | ELERREKVKI | KNEEEFKEKN | GDAAFKAMKT | LGETFLTKIN | EVTL |