B4I0W6

PR
Gene name
Cbp80 (GM12358)
Protein name
Nuclear cap-binding protein subunit 1
Names
80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit
Species
Drosophila sechellia (Fruit fly)
KEGG Pathway
dse:6612480
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4I0W6

Entry ID Method Resolution Chain Position Source
AF-B4I0W6-F1 Predicted AlphaFoldDB

No variants for B4I0W6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4I0W6

No associated diseases with B4I0W6

3 regional properties for B4I0W6

Type Name Position InterPro Accession
domain MIF4G-like, type 3 31 - 243 IPR003890
domain MIF4G-like, type 1 348 - 473 IPR015172
domain MIF4G-like, type 2 488 - 770 IPR015174

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear cap binding complex A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
RNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.

7 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
negative regulation of viral genome replication Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
post-transcriptional gene silencing by RNA A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.
primary miRNA processing A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRRRAHDTE DEGYDHRRNK RRRVSENQEI EDRLESLILR VGERSTSSVE SNLEGLVSVL
70 80 90 100 110 120
EADLGTFRLK ILRILSDCAV RMPEKCTVYT TLVGLLNAKN YKFGGEFVDH MVKTFKESLK
130 140 150 160 170 180
MCRWDAARYS LRFLADLVNC HVISATSLLQ LLDTMIDVSN EDTVPQVRRD WFVFAVLSTL
190 200 210 220 230 240
PWVGRDLYEK KESALESLLL RIEVYLNKRS KKHHNALRVW SSDAPHPQEE YLDCLWAQIR
250 260 270 280 290 300
KLRQDNWAEK HIPRPYLVFD SILCEALQHN LPTIVPPPHH DNFEYPMPWV VYRMFDYTDC
310 320 330 340 350 360
PDGPNLPGAH SIERFLIEEH LHHIIETYHH ERKDCAAQLL SFPYKHKIPL EYCIVEVVFA
370 380 390 400 410 420
ELFHMPTPRY LDICYGSILI ELCKLQPATL PQVLAQATEI LFMRIDSMNT SCFDRFVNWF
430 440 450 460 470 480
SYHLSNFKFT WSWDEWDSWL LLDGEHPRPK FIQEVLQKCL RLSYHQRITE MMPTTYAKLI
490 500 510 520 530 540
PLTPVPNYKY ANEEAASLPG TTVAHQLVVA IRQKCTPEEV VNILKDIPNS GYSGEEMSDG
550 560 570 580 590 600
SFNALKIDVF VQTLLNLGSK SFSHSFAAIS KFHSVFRALA ETEEAQICIL HNIFELWSSH
610 620 630 640 650 660
QQMMVVLIDK LLKLQIVDCS AVATWIFSKE MTGEFTKLYL WEILHLTIKK MNKHVIKLNS
670 680 690 700 710 720
ELSEAKDKLA KADSSSSDSE DDSSHKRKKP ITHADKPSEE VVERMEEKLE AANVNQKRLF
730 740 750 760 770 780
LIVFQRFIMI LSEHLLRSDT DGRDPDTDWY RWTIGRLQQV FLMHHEQVQK YSSTLETLLF
790
TSDLDTHILE VFQQFVALRA