B4HST0

PR
Gene name
calypso (GM20083)
Protein name
Ubiquitin carboxyl-terminal hydrolase calypso
Names
BAP1 homolog
Species
Drosophila sechellia (Fruit fly)
KEGG Pathway
dse:6609392
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

371-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4HST0

Entry ID Method Resolution Chain Position Source
AF-B4HST0-F1 Predicted AlphaFoldDB

No variants for B4HST0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4HST0

No associated diseases with B4HST0

2 regional properties for B4HST0

Type Name Position InterPro Accession
domain Peptidase C12, ubiquitin carboxyl-terminal hydrolase 44 - 277 IPR001578
domain Peptidase C12, C-terminal domain 348 - 393 IPR041507

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
  • Nucleus
  • Localizes to PcG response elements (PREs)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
PR-DUB complex A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.

4 GO annotations of biological process

Name Definition
heterochromatin assembly An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
monoubiquitinated histone H2A deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
specification of segmental identity, abdomen The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNAAGGGSGA QAAGVAAGNI SLSHNALLST ASGATTMPMA QLADGWLELE SDPGLFTLLL
70 80 90 100 110 120
KDFGCHDVQV EEVYDLQKPI ESPYGFIFLF RWIEERRARR KIVETTAEIF VKDEEAISSI
130 140 150 160 170 180
FFAQQVVPNS CATHALLSVL LNCNENNLQL GDTLSRLKTH TKGMSPENKG LAIGNTPELA
190 200 210 220 230 240
CAHNSHAMPQ ARRRLERTGA GVSSCRFTGE AFHFVSFVPI NGQLFELDGL KPYPMNHGGW
250 260 270 280 290 300
EDSEDWTDKF RRVMAERLGI ATGEQDIRFN LMAVVPDRRI AITHKLKMLR TNQAIVSGTL
310 320 330 340 350 360
QKLLKADEQG ESGNGDSQRP DTPTTLLEPS AFTARDLQSL LKNLDTEIAI NEQHLTDEND
370 380 390 400 410 420
RRHMFKVDAS RRTHNYDKFI CTFLSMLAHQ GVLGELVSQH LLPSKKVSGQ GAANRISKQS
430 440 450 460 470
NTASAGGSTT GASASTPKTQ QQQAAAAKNG KSPSKTPGRR RKGRNKCRKR K