B4HK67

PR
Gene name
eIF3-S6 (Int6, GM24367)
Protein name
Eukaryotic translation initiation factor 3 subunit E
Names
eIF3e, Eukaryotic translation initiation factor 3 subunit 6
Species
Drosophila sechellia (Fruit fly)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4HK67

Entry ID Method Resolution Chain Position Source
AF-B4HK67-F1 Predicted AlphaFoldDB

No variants for B4HK67

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4HK67

No associated diseases with B4HK67

2 regional properties for B4HK67

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 218 - 404 IPR000717
domain Eukaryotic translation initiation factor 3 subunit E, N-terminal 5 - 135 IPR019010

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

1 GO annotations of molecular function

Name Definition
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MANFDLTRIN CQFLDRHLTF PLLEFLCGKE IYNQQELLEY ILETVNKTNM IDYTMDTRKR
70 80 90 100 110 120
LNLSQEMPEE LVQRKAEVLA TLKQLQNEVA PIMKATDILK NGESMKDSKT FVNALQKDYN
130 140 150 160 170 180
FKVEHLESAY LAKYLYECGN YQESTSYLYF CLIVMSPNDK NYLNVLWGKL AAEILTLNWN
190 200 210 220 230 240
TALEDLTRLR DYIDNANFST IQALQQRTWL IHWSVLVFFN HPKGRDLIIE MFLYKPLYLN
250 260 270 280 290 300
AIQTMCPHIM RYLATAVVIN RTRRNALKDL IKVIQQESYT YRDPITEFLE CLYVNFDFEG
310 320 330 340 350 360
ARLKLHECQT VILNDFFIVA CLNEFVEDAR LMIFETFCRI HQCITISMLA DKLNMKPNEA
370 380 390 400 410 420
ECWIVNLIRN ARLNAKIDSK LGHVVMGTQP LSPYQQLVEK IDSLSMRSEH LAGLIERKSK
430
QKQNQESADS WKYY