B4H3U8

PR
Gene name
sws
Protein name
Neuropathy target esterase sws
Names
Swiss cheese
Species
Drosophila persimilis (Fruit fly)
KEGG Pathway
EC number
3.1.1.5: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1377-1435 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4H3U8

Entry ID Method Resolution Chain Position Source
AF-B4H3U8-F1 Predicted AlphaFoldDB

No variants for B4H3U8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4H3U8

No associated diseases with B4H3U8

5 regional properties for B4H3U8

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 118 - 148 IPR000571-1
domain Zinc finger, CCCH-type 161 - 186 IPR000571-2
conserved_site tRNA-dihydrouridine synthase, conserved site 390 - 408 IPR018517
domain DUS-like, FMN-binding domain 306 - 553 IPR035587
domain E3 ligase, CCCH-type zinc finger 122 - 146 IPR041367

Functions

Description
EC Number 3.1.1.5 Carboxylic ester hydrolases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
  • Sws tethers Pka-C3 to the membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
phosphatidyl phospholipase B activity Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate.
protein kinase A catalytic subunit binding Binding to one or both of the catalytic subunits of protein kinase A.

11 GO annotations of biological process

Name Definition
ensheathment of neurons The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.
glial cell apoptotic process Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
membrane lipid metabolic process The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.
membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
negative regulation of cAMP-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.
neuron apoptotic process Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
photoreceptor cell maintenance Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
protein localization to membrane A process in which a protein is transported to, or maintained in, a specific location in a membrane.
sensory perception of smell The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDVLELLRVS GSNMYYSTFL ADAWCYYISN QITMTMYLYC ALGVLSMLFI GWFVYFKRLA
70 80 90 100 110 120
RLRLRHEIAR SLSAVTMASG GDLRGPRFRK RDKMLFYGRR MLRKMKNVSG QMYSSGKGYK
130 140 150 160 170 180
RRAVIRFARR ILQLRRENMP LEVRTVEPPA EYLEETMEGS DRVPPDALYM LQSIRIFGHF
190 200 210 220 230 240
EKPIFLRLCK HTQLLELMGG DYLFKITDPD DSVYIVQSGM INVYISNADG STLSLKTVRK
250 260 270 280 290 300
GESVTSLLSF IDVLSGNPSY YKTVTAKAIE KSVVIRLPMA AFQEVFKDSP DVMIRVIQVI
310 320 330 340 350 360
MIRLQRVLFT ALRNYLGLNA ELVQNHMRFK GSSQGAGPSV YCSQTTRQAT GSASATATAA
370 380 390 400 410 420
AASGTAGSTH TAVPRPASSL SRYSQDEQHT LSDPNPGIPN LELSGDSVNT LFGEVNGGAR
430 440 450 460 470 480
LNSYPPLYHQ RESDGNLSTR RGSITQQEQP EVGPVPSIDM RLVKSSAVDS LRKELGLPEQ
490 500 510 520 530 540
DAHIIDPFVE VREMEPNVTL ITEGNADDVC VWFVMTGTLA VYQGNADATR IKQDKTDLLI
550 560 570 580 590 600
HYVHPGEIVG GLAMLTGEAS AYTIRSRNHS RVAFIRRAAI YQIMRQRPRI VLDLGNGVVR
610 620 630 640 650 660
RLSPLVRQCD YALDWIFLES GRALYRQDES SDSTYIVLSG RMRSVITHPG GKKEIVGEYG
670 680 690 700 710 720
KGDLVGIVEM ITETSRTTTV MAVRDSELAK LPEGLFNAIK LRYPIVVTKL ISFLSHRFLG
730 740 750 760 770 780
SMQTRTTTGA PGAPVEANPV THKYSTVALV PITDDVPLTP FTYELYHSLC AIGPVLRLTS
790 800 810 820 830 840
DLARKQLGMN IFDASNEYRL TSWLAQQEDR NIITLYQCDN ALSPWTQRCM RQADVVLIVG
850 860 870 880 890 900
LGDHSHLVGK FEREIDRLAL RTQKELVLLY PETASSKPAN TLSWLNARPW VTKHHHVLCV
910 920 930 940 950 960
KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN SIGLVLGGGG ARGAAHIGML
970 980 990 1000 1010 1020
KAIQEAGIPI DMVGGVSIGA LMGALWCSER NITTVTQKAR EWSKKMTKWF LQLLDLTYPI
1030 1040 1050 1060 1070 1080
TSMFSGREFN KTIHETFGDV NIEDLWIPYF TLTTDITASC HRIHTNGSLW RYVRSSMSLS
1090 1100 1110 1120 1130 1140
GYMPPLCDPK DGHLLLDGGY VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT
1150 1160 1170 1180 1190 1200
NNVPADVMHN LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT APVKVPDLPD
1210 1220 1230 1240 1250 1260
IQSRLAYVSC VRQLEEVKNS DYCEYIRPLI NKYQTLSCAG CPETYGLNPS DLFSEDEDCD
1270 1280 1290 1300 1310 1320
GYISEPTTLN TDVRRYQVPR GGNSLSLSET EMDMDSDVEM DLKMERKMDK ATQSTPPLQS
1330 1340 1350 1360 1370 1380
KAQILRRKHS KEEARHEWEI KREQKQELAR EQELEREREL SQKGTTAGAT GYTPNAVIAT
1390 1400 1410 1420 1430
QTSLIFMDEE DEMDKKKTKD NDRDEVRGSA EDTGKEKEED KENRSNTNNE TKNYL