B4GXS1

PR
Gene name
Pgam5
Protein name
Serine/threonine-protein phosphatase Pgam5, mitochondrial
Names
Phosphoglycerate mutase family member 5 homolog
Species
Drosophila persimilis (Fruit fly)
KEGG Pathway
dpe:6598375
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4GXS1

Entry ID Method Resolution Chain Position Source
AF-B4GXS1-F1 Predicted AlphaFoldDB

No variants for B4GXS1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4GXS1

No associated diseases with B4GXS1

No regional properties for B4GXS1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for B4GXS1

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

4 GO annotations of molecular function

Name Definition
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein serine/threonine kinase activator activity Binds to and increases the activity of a protein serine/threonine kinase.

5 GO annotations of biological process

Name Definition
peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
positive regulation of mitochondrial fission Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
response to anesthetic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKFTAFACG TGAGLLTFYL TKLNEPKAAV HNSWTRSEKP VDPCALWDHN WDLRDPKSLV
70 80 90 100 110 120
KPVKNDLSQE QNRYNTELEK VVPKHARHII LIRHGEYLDV GDTDETHHLT ERGREQAKYT
130 140 150 160 170 180
GKRLCELGIK WDKVIASTMV RAQETADIIL NEIDYEKTKV KNCAFLREGA PIPPQPPVGH
190 200 210 220 230 240
WKPEASQFFR DGARIEAAFR RYFYRAYPDQ TKDSYTLLVG HGNVIRYFVC RALQFPPEAW
250 260 270 280
LRISINHASI TWLTISPSGN VSIKYLGDTG FMPVNHLTNR IPRAAKNVV