B4F753

PR
Gene name
abhd12
Protein name
Lysophosphatidylserine lipase ABHD12
Names
2-arachidonoylglycerol hydrolase ABHD12, Abhydrolase domain-containing protein 12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100216158
EC number
3.1.1.23: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4F753

Entry ID Method Resolution Chain Position Source
AF-B4F753-F1 Predicted AlphaFoldDB

No variants for B4F753

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4F753

No associated diseases with B4F753

1 regional properties for B4F753

Type Name Position InterPro Accession
domain Serine aminopeptidase, S33 162 - 276 IPR022742

Functions

Description
EC Number 3.1.1.23 Carboxylic ester hydrolases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
acylglycerol lipase activity Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
palmitoyl-(protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid.

4 GO annotations of biological process

Name Definition
acylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
monoacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
phosphatidylserine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKRAEPVPP EHESFGRAPL DRECSIKQKL RIPGTKGHYP HDSDCDSKGM KRFGRRYGLW
70 80 90 100 110 120
SRLRMFLIFL LGLYIAIPFL VKICPAIQTQ LVFLNLVRFP YFIDLKRPED QGLNHTCNFY
130 140 150 160 170 180
LQPEEDVSIG VWHTVPAVLW KDAQGKDLEW YEEVLSTSYP VILYLHGNAG TRGGDHRVQL
190 200 210 220 230 240
YKVLSSMGYH VISFDYRGWG DSVGSPSESG MTYDALHVFD WIKARSGDNP VYIWGHSLGT
250 260 270 280 290 300
GVATNLVRRL CERETPPDSL ILESPFTNIR EEAKSHPFSV IYRYFPGFDW FFLDPITASG
310 320 330 340 350 360
IKFANDDNVK YISCPLLILH AEDDPVIPFH LGKKLYNIAA PARSLRDYKV QFVPFHKDLG
370 380
YRHKYIYRSP ELRQILRDFL GNTEQQ