B4F2C3

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Proteus mirabilis (strain HI4320)
KEGG Pathway
pmr:PMI3422
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

660-709 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4F2C3

Entry ID Method Resolution Chain Position Source
AF-B4F2C3-F1 Predicted AlphaFoldDB

No variants for B4F2C3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4F2C3

No associated diseases with B4F2C3

9 regional properties for B4F2C3

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 16 - 144 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 324 - 456 IPR001247-2
domain S1 domain 619 - 690 IPR003029
domain K Homology domain 552 - 617 IPR004087
domain K Homology domain, type 1 556 - 614 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 147 - 210 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 461 - 528 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 242 - 320 IPR015848
domain RNA-binding domain, S1 620 - 690 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNPTVRKFQ YGQHTVTLET GMMARQATAA VMVDMDGTAV FVTVVAKKKV KEGQDFFPLT
70 80 90 100 110 120
VNYQERSYAA GRIPGSFFRR EGRPGEGETL IARLIDRPLR PLFPEGFLNE IQVVATVVSV
130 140 150 160 170 180
NPQVNPDIVA MIGASAALSL SGVPFNGPIG GARVGFIDGQ YVLNPTVDEL KISKLDLVVA
190 200 210 220 230 240
GTAGAVLMVE SEADLLSEEQ MLGAVVFGHE QQQVVIENIN ALVAEVGKEK WDWAPEPINQ
250 260 270 280 290 300
SLHDRIAQLA QTRIGDAYRI TEKQERYEQI DAIRDEVIST LLAEDESLDE GEIIEIFSGL
310 320 330 340 350 360
EKKIVRARVL AGEPRIDGRE KDMVRALDIR TGLLPRTHGS ALFTRGETQA LVTATLGTAR
370 380 390 400 410 420
DAQTIDDIMG EHTDTFLLHY NFPPYSVGET GMMGSPKRRE IGHGRLAKRG VLAVMPTIEE
430 440 450 460 470 480
FPYTVRVVSE ITESNGSSSM ASVCGASLAL MDAGVPIKES VAGIAMGLVK EGENFVVLSD
490 500 510 520 530 540
ILGDEDHLGD MDFKVAGSRN GVSALQMDIK IEGITREIMQ VALNQAKSAR LHILGVMESA
550 560 570 580 590 600
ISQPRAEISE FAPRIHTIKI NADKIKDVIG KGGSVIRALT EETGTTIEIE DDGTVKIAAT
610 620 630 640 650 660
SGEQAKQAIA RIEEITAEVE VGRIYNGKVT RIVDFGAFVA IGGGKEGLVH ISQIADKRVE
670 680 690 700
KVSDYLTMGQ EVPVKVLEID RQGRIRLSMK EAQATQQEAA ETSSEDPAN