B4EJ37
Gene name |
metE |
Protein name |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase |
Names |
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme |
Species |
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) |
KEGG Pathway |
bcj:BCAM2484 |
EC number |
2.1.1.14: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B4EJ37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B4EJ37-F1 | Predicted | AlphaFoldDB |
No variants for B4EJ37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B4EJ37 | |||||
No associated diseases with B4EJ37
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.14 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methionine biosynthetic process | The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVTTHNLGFP | RIGAKRELKF | GLERYWKGES | SRDELKALGA | ELRRRHWHDQ | RDLDLAPIGD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FAFYDQVLDM | SFTLGNLPKR | VQDFHGDALD | NAFRVARGRS | AQSAEAHAAC | CGGVAAGEMT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KWFDTNYHYI | VPEFHADTNF | SLDPSRLLQQ | LAEANAQGVN | AKPVILGPVT | YLWLGKAKDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDRLALLPKL | LPVYGALLDT | LTAQGVEWVQ | IDEPILVTEL | DAEWRQAFRT | AYAALETRRI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLLLATYFGQ | LQDNLTLAAS | LPVDGLHIDA | INARDEVDAL | VRELPPERVL | SIGAINGRNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WKTDLNATLD | WLEPLAKQLG | DRLWLAPSCS | LLHVPVDLAN | EAKLDAEIRS | WLAFALQKLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELKVLATALN | EGRDTVADAL | AANAAAIESR | RRSPRVNNPA | VKAAIARIDA | RLGNRASPYA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QRASKQSARL | NLPAFPTTTI | GSFPQTAEIR | QARSRFKAGT | LDEAGYRTAM | QAEIERSVRE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QESLELDVLV | HGEAERNDMV | EYFGEQLDGY | AFSQFGWVQS | YGSRCVKPPI | LFGDISRPKA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MTVEWITYAQ | SLTNKPMKGM | LTGPVTILNW | SFVRDDQPRS | VSCYQLALAI | RDEVLDLEQA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GVRVIQIDEA | ALREGLPLRR | AQWSEYLKWA | VESFRITANG | VQDDTQIHTH | MCYSEFNDII |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ASIADMDADV | ITIETSRSDM | ELLDAFDDFK | YPNEIGPGVY | DIHSPNIPTQ | DHIVGLMRKA |
| 730 | 740 | 750 | 760 | ||
| AERIPAERLW | VNPDCGLKTR | QWGEVIPALT | NMVAAAKTLR | NQVR |