B4EFI8

PR
Gene name
BceJ2315_55590 (BCAM2122)
Protein name
Acetaldehyde dehydrogenase 2
Names
Acetaldehyde dehydrogenase [acetylating] 2
Species
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
KEGG Pathway
bcj:BCAM2122
EC number
1.2.1.10: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

130-203 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B4EFI8

Entry ID Method Resolution Chain Position Source
AF-B4EFI8-F1 Predicted AlphaFoldDB

No variants for B4EFI8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B4EFI8

No associated diseases with B4EFI8

2 regional properties for B4EFI8

Type Name Position InterPro Accession
domain Semialdehyde dehydrogenase, NAD-binding 6 - 122 IPR000534
domain Acetaldehyde dehydrogenase, C-terminal 129 - 282 IPR015426

Functions

Description
EC Number 1.2.1.10 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
acetaldehyde dehydrogenase (acetylating) activity Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

1 GO annotations of biological process

Name Definition
aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDRVKVAII GPGNIGTDLM IKIMRNGRHL KMGAMVGVDP NSEGLARAAR MDVATTAEGI
70 80 90 100 110 120
DGLLRLDVFK EIDIVFDATS AGAHGRHNEL LQAHGVQVID LTPAAIGPYV IPSINLEEEN
130 140 150 160 170 180
ATNMNMVTCG GQATIPIVAA VSRIAKVHYA EIVASISSRS AGPGTRANID EFTETTRAAI
190 200 210 220 230 240
EKLGGAERGK AIIVLNPAEP PLIMRDTVFV LSENAEPAAI EASIAEMVSS VQEYVPGYRL
250 260 270 280 290 300
KQSVQFDAVP PDMPLNVPGI GPRHGLKTSV FLEVEGAAHY LPSYAGNLDI MTSAALACGD
310
MMARRRMAAG IARGFKETAR