B3MIV9

PR
Gene name
calypso (GF12763)
Protein name
Ubiquitin carboxyl-terminal hydrolase calypso
Names
BAP1 homolog
Species
Drosophila ananassae (Fruit fly)
KEGG Pathway
dan:6495610
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

398-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B3MIV9

Entry ID Method Resolution Chain Position Source
AF-B3MIV9-F1 Predicted AlphaFoldDB

No variants for B3MIV9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B3MIV9

No associated diseases with B3MIV9

2 regional properties for B3MIV9

Type Name Position InterPro Accession
domain Peptidase C12, ubiquitin carboxyl-terminal hydrolase 42 - 275 IPR001578
domain Peptidase C12, C-terminal domain 346 - 391 IPR041507

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
  • Nucleus
  • Localizes to PcG response elements (PREs)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
PR-DUB complex A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.

3 GO annotations of biological process

Name Definition
heterochromatin assembly An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
monoubiquitinated histone H2A deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNMTGGGAGP QAGPNSSCNI PNSSLLATAP VAATMPIAQL ADGWLELESD PGLFTLLLED
70 80 90 100 110 120
FGCHDVQVEE VYDLQKPIES PYGFIFLFRW IEERRARRKI VETTAEIFVK DEEAISSIFF
130 140 150 160 170 180
AQQVVPNSCA THALLSVLLN CNENNLQLGD TLSRLKAHTK GMSPENKGLA IGNTPELACA
190 200 210 220 230 240
HNSHAMPQAR RRLERTGAGV SSCRFTGEAF HFVSFVPING QLFELDGLKP YPMNHGGWED
250 260 270 280 290 300
HEDWTDKFRR VMTERLGIAT GEQDIRFNLM AVVPDRRIAI THKLKMLRTN QAIVSGTLQK
310 320 330 340 350 360
LLKADEQGEG GNGDPQRPDT PSTLLEPSAF TARDLQSLLK NLDTEIAINE QHLADENDRR
370 380 390 400 410 420
HKFKVDASRR THNYDKFICT FLSMLAHQGV LGELVSQHLL PSKKISGQSA ANRLNKQSNA
430 440 450 460
TANAGATAAG AAGAAPKSQQ QQAAAAKNGK SPSKTPGRRR KGRNKCKKRK