B3M996

PR
Gene name
Las
Protein name
Lipoyl synthase, mitochondrial
Names
Lipoate synthase, LS, Lip-syn, Lipoic acid synthase
Species
Drosophila ananassae (Fruit fly)
KEGG Pathway
dan:6506768
EC number
2.8.1.8: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B3M996

Entry ID Method Resolution Chain Position Source
AF-B3M996-F1 Predicted AlphaFoldDB

No variants for B3M996

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B3M996

No associated diseases with B3M996

3 regional properties for B3M996

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 124 - 330 IPR006638
domain Radical SAM 62 - 358 IPR007197
domain Lipoyl synthase, N-terminal 16 - 108 IPR031691

Functions

Description
EC Number 2.8.1.8 Sulfurtransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLRALKGHVE SPLIVVTRAA STNAEKLEEI RERLAKGPNF QDFVQNPDYS KSEWENYEGK
70 80 90 100 110 120
LRREKGEEQR LRLPPWLKTT IPMGKNYAKI KNQLRELKLS TVCEEARCPN IGECWGGGEH
130 140 150 160 170 180
GTQTATIMLM GDTCTRGCRF CSVKTARKPP PLDENEPVNT ATAIASWGLD YIVLTSVDRD
190 200 210 220 230 240
DLPDGGSKHI AKTVKEIKAR NSNIFVECLV PDFRGDLGCV ETIANCGLDV YAHNIETVEK
250 260 270 280 290 300
LTPYVRDRRA HYRQTLKVLS EAKRFNPNLI TKSSIMLGLG ETDEEVENTL KDLREAGVDC
310 320 330 340 350 360
ITLGQYMQPT NKHLKVIEYV TPEKFKHWED RGNQLGFLYT ASGPLVRSSY KAGEFFITSI
370
LENRKKRQAL NSKPEQ