B3LF48
PR
Gene name |
EHD2 |
Protein name |
EH domain-containing protein 2 |
Names |
AtEHD2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G05520 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B3LF48
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B3LF48-F1 | Predicted | AlphaFoldDB |
44 variants for B3LF48
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02673001 | 6 | T>A | No | 1000Genomes | |
| ENSVATH06486272 | 19 | I>M | No | 1000Genomes | |
| ENSVATH06486273 | 25 | N>K | No | 1000Genomes | |
| ENSVATH13953975 | 26 | I>M | No | 1000Genomes | |
| ENSVATH06486276 | 33 | G>D | No | 1000Genomes | |
| ENSVATH06486277 | 34 | R>L | No | 1000Genomes | |
| ENSVATH06486278 | 37 | G>S | No | 1000Genomes | |
| ENSVATH06486279 | 38 | N>H | No | 1000Genomes | |
| tmp_4_2804764_G_C | 51 | R>P | No | 1000Genomes | |
| tmp_4_2804967_C_T | 72 | S>L | No | 1000Genomes | |
| tmp_4_2805104_T_A | 90 | I>N | No | 1000Genomes | |
| tmp_4_2805121_A_G | 96 | K>E | No | 1000Genomes | |
| ENSVATH00467149 | 105 | E>V | No | 1000Genomes | |
| ENSVATH13953979 | 110 | E>G | No | 1000Genomes | |
| ENSVATH02673009 | 115 | V>I | No | 1000Genomes | |
| tmp_4_2805291_C_A | 117 | S>* | No | 1000Genomes | |
| ENSVATH06486295 | 136 | P>S | No | 1000Genomes | |
| tmp_4_2805539_C_A | 139 | T>K | No | 1000Genomes | |
| ENSVATH00467150 | 155 | V>L | No | 1000Genomes | |
| ENSVATH00467151 | 169 | T>A | No | 1000Genomes | |
| tmp_4_2805733_T_G | 172 | L>R | No | 1000Genomes | |
| ENSVATH06486303 | 183 | D>N | No | 1000Genomes | |
| tmp_4_2806141_C_T | 233 | T>I | No | 1000Genomes | |
| tmp_4_2806140_A_C | 233 | T>P | No | 1000Genomes | |
| ENSVATH06486316 | 281 | P>L | No | 1000Genomes | |
| ENSVATH00467171 | 383 | L>V | No | 1000Genomes | |
| ENSVATH13953981 | 390 | R>H | No | 1000Genomes | |
| tmp_4_2807006_A_G | 397 | N>S | No | 1000Genomes | |
| tmp_4_2807015_C_T | 400 | P>L | No | 1000Genomes | |
| ENSVATH06486323 | 402 | N>S | No | 1000Genomes | |
| ENSVATH10798060 | 410 | G>E | No | 1000Genomes | |
| ENSVATH13953982 | 415 | E>Q | No | 1000Genomes | |
| ENSVATH00467178 | 428 | V>I | No | 1000Genomes | |
| ENSVATH00467180 | 446 | S>A | No | 1000Genomes | |
| tmp_4_2807240_G_A | 447 | A>T | No | 1000Genomes | |
| ENSVATH00467181 | 454 | M>I | No | 1000Genomes | |
| tmp_4_2807324_A_G | 475 | M>V | No | 1000Genomes | |
| ENSVATH00467183 | 479 | E>D | No | 1000Genomes | |
| tmp_4_2807349_G_C | 483 | G>A | No | 1000Genomes | |
| ENSVATH00467186 | 486 | Q>H | No | 1000Genomes | |
| ENSVATH00467189 | 510 | N>T | No | 1000Genomes | |
| tmp_4_2807753_A_T | 521 | M>L | No | 1000Genomes | |
| ENSVATH06486333 | 523 | Q>E | No | 1000Genomes | |
| ENSVATH00467190 | 535 | D>N | No | 1000Genomes |
No associated diseases with B3LF48
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| G protein activity | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7TQ48 | Srl | Sarcalumenin | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METSSTISIG | SCLKEHQKIY | KEWFNIADSD | GDGRVSGNDA | TKFFAMSKLS | RQELKQVWAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ADSKRQGFLG | LSEFITAMKL | VSLAQEGHEI | TSDLLKGSID | MKSVELPVLE | GLENVVSKQK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSKTNVDVED | NVVTKPQVTA | KTPWFKSKSI | IKPQVNVVTI | VDGLKRLYTE | KLKPLEVTYR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FNDFASPVLT | SSDFDAKPMV | MLLGQYSTGK | TTFIKHLLGC | DYPGAHIGPE | PTTDRFVVAM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGPDERTIPG | NTMAVQADMP | FNGLTSFGGA | FLSKFECSQM | PHPVLDQITL | VDTPGVLSGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KQRMQRSYDF | TGVISWFASK | CDMILLLFDP | HKLDISDEFK | RVITSLRGNE | DKIRVVLNKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DQVDTQQLMR | VYGALMWSLG | KVLNTPEVVR | VYIGSFNDKP | INEVAVGPIG | KELFEKEQND |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLADLMDVPK | KACDRKINEF | VKRARSAKIN | AYIMSHLKKE | MPAMMGKSKA | QQRLMDNLEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EFGKVQREFH | LPAGDFPSVE | HFREVLGGYN | IDKFEKLKPK | MIQAVDDMLG | YDIPDLLKKF |
| RNPYDN |