B3E164

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4))
KEGG Pathway
min:Minf_0805
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

179-249 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B3E164

Entry ID Method Resolution Chain Position Source
AF-B3E164-F1 Predicted AlphaFoldDB

No variants for B3E164

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B3E164

No associated diseases with B3E164

7 regional properties for B3E164

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 348 - 389 IPR000722-1
domain RNA polymerase, alpha subunit 398 - 489 IPR000722-2
domain RNA polymerase, N-terminal 239 - 518 IPR006592
domain RNA polymerase Rpb1, domain 3 493 - 649 IPR007066
domain RNA polymerase Rpb1, domain 1 20 - 346 IPR007080
domain RNA polymerase Rpb1, domain 5 762 - 1298 IPR007081
domain RNA polymerase Rpb1, domain 4 678 - 759 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEAKNLTARQ VLGFQKTIGF DEVRISIASP ETIESWSKGE VRNPETINYR TFKPEKGGLF
70 80 90 100 110 120
CERIFGPTKD WECACGKYKR IKYKGVICDR CGVEVTLSRV RRERMGHIKL AVPVSHIWFL
130 140 150 160 170 180
KCMPSRLGLI MDMTAKDLER VIYYEDYLVV DPGKTPLRFK QLLSEQEYRD ALAQYGEEAF
190 200 210 220 230 240
VAKMGAEAVR DILKQIDLQA LANDLTAAME GTRSKQLKKK LAKRLKLVQG LINSETRPEW
250 260 270 280 290 300
MILEVLPVIP PDLRPLVPLE GGRFATSDLN DLYRRVINRN NRLKNLLQLK TPDVIIRNEK
310 320 330 340 350 360
RMLQEAVDAL LDNGRHGRAV TGAGNRPLKS LSDMLQGKTG RFRMNLLGKR VDYSGRSVIV
370 380 390 400 410 420
IGPELKLHQC GLPKKMALVL FEPFMIRRLR ELGHVHTVRT AKKMIEKQDP LVWDVLEQVT
430 440 450 460 470 480
AGHLVLLNRA PTLHRLSIQA FEPILIEGDA IRIHPLVCTA YNADFDGDQM AVHVPLSIEA
490 500 510 520 530 540
QLEARLLMLA PLNIFSPSSG KPITTPTQDI TLGCYYLTQP PLKIKVQEQK RKPLFSDAQE
550 560 570 580 590 600
VIFAYNDGLL QMHDLILLKN PDYGRSTVFG DKNKKVIETT PGRVIFNQIW PPELGFYNKP
610 620 630 640 650 660
AGKKQLGEII LKCYQTVGRE KTVQCLDNLK ELGFAEATKA GISIGIDDMI VPAEKTRIIS
670 680 690 700 710 720
KAYEMVNVVE RQYRSGAITD GERYNKIVDI WTQATEEISG VIYKSLENNL GRPEYNPLFL
730 740 750 760 770 780
MVDSGARGNR QQVRQLAGIR GLMAKPSGEI IERPIISNFR EGLSVLEYFI STHGARKGLA
790 800 810 820 830 840
DTALKTADAG YLTRKLHDVA QDVVITMQDC GTNKGIIVQA IYEGDEEIVK LSERIYGRVC
850 860 870 880 890 900
CDEIIDPMTG RIVVRPGELI DEKKAKEIEE AGAEKVKIRS VLTCESKWGV CASCYGLNLA
910 920 930 940 950 960
TNRMARLGES VGVIAAQSIG EPGTQLTMRT FHIGGTASQV FKQPQIRARN DGIVQYIDLR
970 980 990 1000 1010 1020
TVKTVDNHFI VLSKSGYLAV LDPSGRELER HTVIVGSIIL IPDGEMVKKG QVFVQWDPYN
1030 1040 1050 1060 1070 1080
VPILTEKGGI VEFRDIIEGV TVKKELDETT KQISTIVIEH KHDLHPQILI LDENTREVIA
1090 1100 1110 1120 1130 1140
FYGIPAGARI EVKPGDKVVA GQRIARTPRK MVQTKDITGG LPRVAELFEA RKPKDSAEIA
1150 1160 1170 1180 1190 1200
KIDGIVEDGG IIRGKRRILI RDPQTGSEEE HLIPLSKHLI VYKGDVVKKG QQLTEGPIVP
1210 1220 1230 1240 1250 1260
QEILDVCGIQ ELQEYLLNEV QEVYRLQGVE INDKHIEIII KQMLKKVKIL DAGDTSFLWE
1270 1280 1290 1300 1310 1320
EQVDRLKFEE ENRIIEAKGG KPAVGIPVLL GITKASLDTD SFIAAASFQD TTRVLTEAAT
1330 1340 1350 1360 1370 1380
LGKVDPLKGF KENIIMGNLI PSGTGFRTYR NIRLVEVAPP EFKEEKKEQK IYGNGEEPAK
EQKWIPQAGT