B3CSS2

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Orientia tsutsugamushi (strain Ikeda) (Rickettsia tsutsugamushi)
KEGG Pathway
ott:OTT_0961
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

790-879 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B3CSS2

Entry ID Method Resolution Chain Position Source
AF-B3CSS2-F1 Predicted AlphaFoldDB

No variants for B3CSS2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B3CSS2

No associated diseases with B3CSS2

9 regional properties for B3CSS2

Type Name Position InterPro Accession
domain Helicase, C-terminal 425 - 626 IPR001650
conserved_site SEC-C motif 859 - 876 IPR004027
domain SecA DEAD-like, N-terminal 5 - 390 IPR011115
domain SecA Wing/Scaffold 608 - 816 IPR011116
domain SecA, preprotein cross-linking domain 227 - 346 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 88 - 246 IPR014001
domain SecA motor DEAD 2 - 610 IPR014018
conserved_site SecA conserved site 488 - 503 IPR020937
domain SecA, C-terminal helicase domain 408 - 580 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

3 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKFIKSIFK TPSDRIIANL KSKIQQVHSA ESSLAKLSNI ELRNKTNEFK ARLANNEPID
70 80 90 100 110 120
NIQYEAFAVV REAAKRTIGI QHYDEQLIGG ILLHQGKVIE MSTGEGKTLV ATLPSYLNAL
130 140 150 160 170 180
IGKGVHVVTV NDYLAQRDSD WMGTIHRFLD ITVGCITSNT NEHARKIAYN SDITYITNNE
190 200 210 220 230 240
LGFDFLRDNM QFTNQSKVQR GCNYAIIDEI DSILIDEART PLIISGPVSD NTSLYPIINK
250 260 270 280 290 300
LITKLNKDDY EMDEKLRNVT LTDSGINKLE TMLAEINILA PNSNSLYDFE NMHLIHYINQ
310 320 330 340 350 360
SLKAHTLFRR NVDYLVKNGK VIIIDEFTGR TMDSRRYSEG LHQALEAKEK VEIQNENQTL
370 380 390 400 410 420
ASITFQNYFR MYTKLSGMTG TAMTEATELK EIYDLDVVTV PTHNPVQRID YNDEIYSTKK
430 440 450 460 470 480
DKYSAIIQLI QECYSKGQPV LVGTVSIEKS EELSKLLHSK KIPHNVLNAK HHDKEASIIA
490 500 510 520 530 540
QAGRIKAITI ATNMAGRGTD IMLGGNAEML VDQSNLTEEE YQEKLKITKM QIEQEKEQVI
550 560 570 580 590 600
NAGGLFVIGT ERHESRRIDN QLRGRCGRQG DPGQTKFFLS LEDDLMRIFA SDRVTKILRT
610 620 630 640 650 660
IGLKDGEAIH HPLINRSLAT AQQKIEAQNY EIRKNLLKYD NVMNDQRKVI YEQRNEAISS
670 680 690 700 710 720
DNVNEILHNL TEELIVETVH KFIPPKSYKE DWNIHELLKE YHHIFNVKLQ PASIEATSSS
730 740 750 760 770 780
SEVIEYLTKT ALDIYKQQEQ DYSAKSANEA IKHIFIKTLD QTWKEHLYTL DHLKQGISLR
790 800 810 820 830 840
AYGQKDPLNE YKREAFDLFK QMLLHLKYLF IQRVARLHID LASSPKSTSS LLETSDNNLK
850 860 870
GKIITENSMA HKYFGKISRN QLCPCNSGKK FKHCHGALK