B3A0L9

PR
Gene name
SLS1
Protein name
Phosphatidylinositol:ceramide inositolphosphotransferase
Names
TbSLS1, Inositol-phosphorylceramide synthase, IPC synthase, Sphingolipid synthase
Species
Trypanosoma brucei brucei
KEGG Pathway
EC number
2.7.8.27: Transferases for other substituted phosphate groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

290-355 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B3A0L9

Entry ID Method Resolution Chain Position Source
AF-B3A0L9-F1 Predicted AlphaFoldDB

No variants for B3A0L9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B3A0L9

No associated diseases with B3A0L9

1 regional properties for B3A0L9

Type Name Position InterPro Accession
domain Sphingomyelin synthase-like domain 219 - 291 IPR025749

Functions

Description
EC Number 2.7.8.27 Transferases for other substituted phosphate groups
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
phosphotransferase activity, for other substituted phosphate groups Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MISYPFFSLS PPGLVPPPMA VPPVEMYSGS FWNRMRKPLP LRTQVIRFTV VFVIVSFILA
70 80 90 100 110 120
VALQITHERM PDPKVTKPLP DLGFELLTKI SFLSVVTDVL IAFLSLLSFF TLWKLYLLHR
130 140 150 160 170 180
HCVGSGEPEL PCNIPGVSRF FLSVWLCKEN CRIELRNIHT IAWIRFITSY ALLLLFRSLV
190 200 210 220 230 240
IVMTSMPTPV DKCQDPPKIE NPVKNVILTV LTAGGGSIHC GDLMVSGHTV ILTLHLMFHW
250 260 270 280 290 300
IYGAMVHWSF RPVVTVVAIF SYYCIVASRS HYTDDVLVAI YLTIATFIAV GHNADGAPWQ
310 320 330 340 350
LQLFIRWLPC CGANSREVTE DSQPVMVAFK SEAVDELRER DDSAGLSGEV STNEV