B2ZDY2

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-229 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for B2ZDY2

Entry ID Method Resolution Chain Position Source

No variants for B2ZDY2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2ZDY2

No associated diseases with B2ZDY2

2 regional properties for B2ZDY2

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, negative-strand RNA virus 1166 - 1367 IPR007099
domain RNA endonuclease, cap-snatching 6 - 171 IPR026382

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

3 GO annotations of molecular function

Name Definition
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
RNA-templated viral transcription A transcription process that uses viral RNA as a template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVDCNDRINE LKDLIRKWVP DEEAYTEQKT TFLSQVNPSS IITEGLKLLS MLIEIDSCLK
70 80 90 100 110 120
HGCVFNRNKT VNQILKDHRI IGPTLPDVVP DGYRVSGSTI ILLETFVRVN QESFEQKYKH
130 140 150 160 170 180
DFEKLIQLSK DLSKCGLILV PVIDGRSNYY VDRFPDWVVE RIRWLLLKLM DNVKDTGERI
190 200 210 220 230 240
EELEYNRLIS SLSSMENQNL GLESLKALRE EGLDYKTKLM EAIRDGIRPN LTASECRIGI
250 260 270 280 290 300
AKVYDQFCLL RDSGQYQNVY CRTSRSEMIE WLKDHKLTSL INGSEGTFFN NERCGFCQNH
310 320 330 340 350 360
MLRVIAELVH SKRVSSNYTP TNDKEISRHK KLLSDCNKIK GLKVLNTRRH TLLCLDVIVL
370 380 390 400 410 420
NSLIEMIKLK INSSQFLINN HFKSVNDRLL SVDLIINKLE KKLLKQPDWL GNVKGKLSKR
430 440 450 460 470 480
IKPYNLDYVI TWLKELDYEF WYEFKFEREH SARYEKPTLR YKRQSERVCY QVEFGTDKIF
490 500 510 520 530 540
NEEVFLEYLD ALSSLSLGMM NSMKTSSATK LVINDEKSFY GTVQCEECYF QDLDSSYNSI
550 560 570 580 590 600
LLYQKTGEKS RCYGLMLNDD ELSDVYRVGQ SFYADPKRFF LPIMSSNVIL KTCEEMLSWL
610 620 630 640 650 660
DWLTNEETNM IRTKLFTLVI NVLTVPSKRV QIYLQGFRYF IMAFVNEFHF KRLNEKLSVQ
670 680 690 700 710 720
ALTSAEHHVF VLMDELVVCL LEEALEENMA KIFKFVLNLS YLCHFITKET PDRLTDQIKC
730 740 750 760 770 780
FEKFLEPKLQ FGSAFVNLDS SPSLPKEIED KFVKDINNLF SKDLHTNDLE SPGLSKEILS
790 800 810 820 830 840
LCTSCFNCGM LTVGKVLQND PQSPSFSSTA LDISSNKSVV VPKLDEVGEI ITHYDYQNLL
850 860 870 880 890 900
SSVVVEMAQS FKDKLRYKLD RKSVQYAIYR RLTNMVLTKN LNEKNHINEN CEDFEEFLDE
910 920 930 940 950 960
DTCRLISDIE SNVLECLSNM ATPPVRKVIK GQEITQRYEG PDLLGRLWSR ELMGPILAET
970 980 990 1000 1010 1020
SLHEVKDFDP SIFSFETYQE LCELIFNSEL KEQFFLDDVL RFCPLELLVK NLTTKNFIEK
1030 1040 1050 1060 1070 1080
DFFECFKYIL ISAGFDNRVG RYDHRSRSRL GFKDAAYHVK EKSRISLRES NSEAVSKRLD
1090 1100 1110 1120 1130 1140
KSFFTNSSLR NLCFYSEESP TFQSTVSSST GKLKFGLSYK EQVGSNRELY VGDLNTKLTS
1150 1160 1170 1180 1190 1200
RLIEDYFESI TSESKFSCLN NDSEFEKAIL DMKSVVRLSG LAVSLDHSKW GPYMSPAIFN
1210 1220 1230 1240 1250 1260
SLFTSLDLQL RDGSLIDKSP IENLLNWHLH KLVEVPYNVI EAYLKGYTKR GLGLMDKMSS
1270 1280 1290 1300 1310 1320
TVCEDFIFNW FAKGQVPSHI SSVLDMGQGI LHNTSDYYGL VTEQFIMLCL ELCFDVRMTA
1330 1340 1350 1360 1370 1380
YTSSDDEIML SNSHSLKDKS DESLDIQKCG ELLEFHYYLS SKLNKFVSPK TVAGSFASEF
1390 1400 1410 1420 1430 1440
KSRFFIWSQE VPLLTKFVAA ALHNVKAKSP HQLAETVDTI LDQCVANGVS IKIIKEISKR
1450 1460 1470 1480 1490 1500
TNRLISYSGH PIDPFLCVVE TDLKDWVDGS RGYRLQRSIE SIIADDKQLS IIRNSCKKLF
1510 1520 1530 1540 1550 1560
YKIRSGDIQE EYLVNALQSS PDDCLRQMLR ITEVDDQTIE KLIEIRWLNL RAFGDLRLVL
1570 1580 1590 1600 1610 1620
RTKIMSGTRI LDREEVPSLI RSVQSKLSKN FVRGAKKIVT DAINKSAFQS SVCSGFIGVC
1630 1640 1650 1660 1670 1680
KSMGSKCVRD GSGGFVYIKS LLSEVVCHHT CETCKPRFSV YCKSALERIS KYSRSLLWDY
1690 1700 1710 1720 1730 1740
FSLVFTNACE LGNWVFSCVE TPKKIPSVVN PNFFWCVKPG SHTELEDKVN MNHVLYSIKR
1750 1760 1770 1780 1790 1800
NFPDLFDEHI APFLSDLSSL KISWVQRIRF LDLCVAMDMS SECLGVISHI MRRKREESYI
1810 1820 1830 1840 1850 1860
VKQNELSLAH MRDSTPLEGG FQLNSLEICR NFLYQIVFES MLHPVLLTTS QFKKYFWYGE
1870 1880 1890 1900 1910 1920
VELLPNDADH DLGQLTQFIM DCKTLNVSRC MSLDDLDVGY VHSKITLSDV FINLSSFIHL
1930 1940 1950 1960 1970 1980
LDWGNLCDYE SFDKIILESG LEQVPIEIGI VVSHVRRSFK FKYDRKTNYH IKCKIIIRKS
1990 2000 2010 2020 2030 2040
ELIMSKVNGV DILEIEVSEI ECFVSGSQGH HISLDGVGLI PLHPLFSGKE LIDFNKLLAD
2050 2060 2070 2080 2090 2100
QSIEFKQVSS VFQKVKLDFK QHVKELRNKF SYKFQGPEQG LSPLHLYRGQ IIERDTIVSR
2110 2120 2130 2140 2150 2160
LDVPVTSKSV FLALEALDAA DHTPFLKSLH TYMKTRMSKS NPCFIRMTQE DLCLLIESYE
2170 2180 2190 2200 2210
VAFANILKSE SDWVEFGDFA LCFSNSLNCI MIADDGGQFK LKGRKCRSAS TNPRPLEIE