B2V3W2

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Clostridium botulinum (strain Alaska E43 / Type E3)
KEGG Pathway
cbt:CLH_1125
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-464 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2V3W2

Entry ID Method Resolution Chain Position Source
AF-B2V3W2-F1 Predicted AlphaFoldDB

No variants for B2V3W2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2V3W2

No associated diseases with B2V3W2

4 regional properties for B2V3W2

Type Name Position InterPro Accession
domain DHHA1 domain 735 - 872 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 655 - 698 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 9 - 557 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 711 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFTKTNDLR DAYLKFFESK DHLKLESFSL VPQNDKSLLL INAGMAPLKP YFTGLQEPPK
70 80 90 100 110 120
KRITTCQKCV RTGDIDNVGI TSRHGTFFEM LGNFSFGDYF KKEIIPWAWE FLTGVLELPK
130 140 150 160 170 180
EKLYVTIYLD DDEAYEYWTT LTDVDKTHIF RLGKEDNFWE HGAGPCGPCT EIHFSRTDEV
190 200 210 220 230 240
PTNSEKFVEL SDEDKIIEVW NLVFTQFDGD GKGNYEKLAS TNIDTGMGLE RLAVVMQNKN
250 260 270 280 290 300
SIFEIDTLEN ILKEVGNLAN VKYGEDNKID VSLRIITDHI RSITFMISDD IMPSNEGRGY
310 320 330 340 350 360
VLRRLLRRAA RHGKTLGIKD AFLCNLCDVV IRDCGSAYSD LEAKKDYIKK VIKIEEDKFR
370 380 390 400 410 420
ETLDSGMEIL NNLISELKEN NEKVLKGADG FKLYDTFGFP MELTKEILED EDLSLDEDGF
430 440 450 460 470 480
HKEMKEQRER ARSARKTSNY MGTDVKTLDV ISGEIETTFD GYENDSLIAE VKTLVNGEDF
490 500 510 520 530 540
TNSIIEGNNA VVVTDVTPFY AEMGGQIGDT GTIYNDNFKG KVLDTKKNIG GKIIHFVEAI
550 560 570 580 590 600
SGELKVGDKV KLEVDNARRE NIKRNHTATH LLDAALVKVL GSHVHQAGSY VSADRLRFDF
610 620 630 640 650 660
SHFEGVKEEE LLKVEQLVNE AIMSVTPVNT TEMDLQEAKN SGAVGIFDDK YAEKVRVVCA
670 680 690 700 710 720
GEYSKELCGG THIDNTGKIG LFKIISENGI AAGTRRIEAV TGIEAYKWVN EKAELLKHIS
730 740 750 760 770 780
GKLKCSEKEI TIKLDQQSKE IKEKEKEITN LKSKFASMEI NDIINSVKDV KGINVVTYAL
790 800 810 820 830 840
TDVDGEALRG LCEKVRDKVN NSLTLLTSSI DGKVVICAMA DKEAVSKGAH CGKVIKEAAT
850 860 870
ILGGGGGGRP DMAQAGGKLP EKISDALDSV YKIVETLVK