B2UXS0

PR
Gene name
asnS
Protein name
Asparagine--tRNA ligase
Names
Asparaginyl-tRNA synthetase, AsnRS
Species
Clostridium botulinum (strain Alaska E43 / Type E3)
KEGG Pathway
cbt:CLH_0134
EC number
6.1.1.22: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

42-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2UXS0

Entry ID Method Resolution Chain Position Source
AF-B2UXS0-F1 Predicted AlphaFoldDB

No variants for B2UXS0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2UXS0

No associated diseases with B2UXS0

2 regional properties for B2UXS0

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 119 - 458 IPR004364
domain Aminoacyl-tRNA synthetase, class II 145 - 454 IPR006195

Functions

Description
EC Number 6.1.1.22 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
asparagine-tRNA ligase activity Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

1 GO annotations of biological process

Name Definition
asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNTVLIKKI YRETDQFLSK EVMISGWIRT LRASNAFGFI EINDGSFFKN IQVVFDDKLG
70 80 90 100 110 120
NFKEISKLPI SSSISVVGTL VATPDAKQPF EIQAKEIVIE GMSNSDYPLQ KKRHTFEYLR
130 140 150 160 170 180
SIAHLRPRSN AFSATFRVRS VAAFAIHKFF QEQGFVYTHT PIITGSDCEG AGEMFRVTTL
190 200 210 220 230 240
DPKAPELTKE GNIDYTKDFF GKETNLTVSG QLNAECFALA FRNIYTFGPT FRAENSNTTR
250 260 270 280 290 300
HAAEFWMIEP EIAFADLQDD MELAEAMLKY VIKYVMDECP EELQFFNSFV DKGLLERLNH
310 320 330 340 350 360
VVSSDFAKVT YTEAVEILEK CDKEFDYDVS WGIDLQTEHE RYLTEEHFKK PLFVTDYPKE
370 380 390 400 410 420
IKAFYMRMNE DNKTVAATDL LVPGIGEIIG GSQREERLDV LEARMAELGL KKEDYWWYLE
430 440 450 460
LRKYGETKHA GFGLGFERLI MYITGMTNIR DVIPFPRTPG TSEF