B2UUX6

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Helicobacter pylori (strain Shi470)
KEGG Pathway
hps:HPSH_06280
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

362-437 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2UUX6

Entry ID Method Resolution Chain Position Source
AF-B2UUX6-F1 Predicted AlphaFoldDB

No variants for B2UUX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2UUX6

No associated diseases with B2UUX6

8 regional properties for B2UUX6

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 20 - 139 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 322 - 454 IPR001247-2
domain S1 domain 624 - 688 IPR003029
domain K Homology domain 549 - 614 IPR004087
domain K Homology domain, type 1 553 - 609 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 145 - 211 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 457 - 527 IPR015847-2
domain RNA-binding domain, S1 624 - 688 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDFITITSSN KTEEFALKQV AKQATSSLMY RLGKTIILAS VCVEREPVGE DFLPLVVQFL
70 80 90 100 110 120
EKSYAAGKIP GGFVKREGRA QDFEILTSRL IDRTLRPLFP KDYRYPTQIT LMVLSHDVEN
130 140 150 160 170 180
DLQVSALNAA SAALFLSHIA PIKSVSACRI ARIGNEFIIN PNTSLLNQSS LDLFVSGTKE
190 200 210 220 230 240
SLNMIEMRSL GQQLNALEEP LMLKALELAQ KSLKETCTLY EEIFTPHQNE LLFKESQGII
250 260 270 280 290 300
FNERLLDLLK NQYFDEIIKG IESSALSERE NVFNEIARKI SEAHSEFSLK EIELSLEKVK
310 320 330 340 350 360
KTEIRCMIIK DKIRPDKRAL EEVRPILIES DLLPMAHSSI LFTRGQTQSL VVGVLGTDND
370 380 390 400 410 420
AQTHESLEHK APIKERFMFH YNFPPFCVGE ASSIGATSRR ELGHGNLAKR ALETSIKNKD
430 440 450 460 470 480
QVIRLVSEIL ESNGSSSMAS VCAGSLALYA SGVEIYDLIA GVAMGMVSEG QDHAILSDIS
490 500 510 520 530 540
GLEDAEGDMD FKIAGNLEGI TAMQMDTKMS GIQLEVLYQA LLQAKKAREH ILKIMHEAKE
550 560 570 580 590 600
KIVINFSHLP TTEIFNVAPD KIVEIIGQGG RVIREIVEKF EVKIDLNKPS GEVKIMGNKE
610 620 630 640 650 660
RVLKTKEFIL NYLHSLDQEL EQYAIDEVLE AQVKRIVDFG AFLSLPKGGE GLLRKQNMDR
670 680
CQVVLKEGDS IKCRVISFNK GKIALDLA