B2UR09
Gene name |
metK |
Protein name |
S-adenosylmethionine synthase |
Names |
AdoMet synthase, MAT, Methionine adenosyltransferase |
Species |
Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc) |
KEGG Pathway |
amu:Amuc_1068 |
EC number |
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B2UR09
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B2UR09-F1 | Predicted | AlphaFoldDB |
No variants for B2UR09
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B2UR09 | |||||
No associated diseases with B2UR09
7 regional properties for B2UR09
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 15 - 26 | IPR001412 |
| domain | tRNA-binding domain | 582 - 683 | IPR002547 |
| domain | Methionyl-tRNA synthetase, beta subunit, C-terminal | 542 - 683 | IPR004495 |
| domain | Methionyl/Leucyl tRNA synthetase | 9 - 396 | IPR015413 |
| domain | Methioninyl-tRNA synthetase core domain | 7 - 371 | IPR033911-1 |
| domain | Methioninyl-tRNA synthetase core domain | 384 - 395 | IPR033911-2 |
| domain | Methionyl-tRNA synthetase, anticodon-binding domain | 374 - 541 | IPR041872 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.6 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| methionine adenosyltransferase activity | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| S-adenosylmethionine biosynthetic process | The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRNTPHIFT | SESVGEGHPD | KVADYISDSI | LDACLAQDKT | SRVACETLVK | SNMVIIAGEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTKAVIDPEK | IARQAIREIG | YCNRQDDDVF | HADTVFFTNL | LTEQSPDIAQ | GVDAREAEGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GHAEQGAGDQ | GIMFGFATNE | TPELLPAPIV | FAHKLLIELA | RRRKRGHVDW | LRPDCKSQVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VAYDEDGRPA | HIENVVISTQ | HTEDVDHDTI | YSYCVKLIKN | VLPAELLDER | TEYFINPTGK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FVVGGPHGDS | GLTGRKIIVD | TYGGMGRHGG | GAFSGKDPSK | VDRSAAYMCR | WVAKHIVAAG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LADKCELQVA | YAIGYPAPVS | IRVDTFGTGK | VEEISIENAL | ENIFSFKPAD | MVEQLNLLRP |
| 370 | 380 | 390 | |||
| IYRKTTHYGH | FTNPELPWEQ | LDETRLASLK | QLLH |