B2UKZ6

PR
Gene name
argC
Protein name
N-acetyl-gamma-glutamyl-phosphate reductase
Names
AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase
Species
Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)
KEGG Pathway
amu:Amuc_1447
EC number
1.2.1.38: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

149-254 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2UKZ6

Entry ID Method Resolution Chain Position Source
AF-B2UKZ6-F1 Predicted AlphaFoldDB

No variants for B2UKZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2UKZ6

No associated diseases with B2UKZ6

3 regional properties for B2UKZ6

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 276 - 285 IPR020557
domain Fumarate lyase, N-terminal 8 - 301 IPR022761
domain Argininosuccinate lyase, C-terminal 365 - 432 IPR029419

Functions

Description
EC Number 1.2.1.38 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
N-acetyl-gamma-glutamyl-phosphate reductase activity Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQVQVAVVG ASGYTGQELL RILLNHRGVK LVCATSRQYA GQPLWEVFPR FRQVPGSGLK
70 80 90 100 110 120
FTDSDVEAIA ATGAEVAFLA LPHGVAASYA RGLVDRGVRV IDLSADFRLD SPDVYEEYYG
130 140 150 160 170 180
NPHPDTALMQ EAVYGLPEWR REEIARARIV ASPGCYPTSI LLPLIPLFRA GMLEPEDVVA
190 200 210 220 230 240
CSGSGVSGAG RKASIPLLFC ECNESFHAYG VPKHRHLSEI EQELSHAAGE TVVMSFTPHL
250 260 270 280 290 300
IPVNTGICST ITAKVKKGAD PESVGRLLEE AYAAAPFVRL LGRNQPADTK NVTRTNCVDI
310 320 330 340
GWAYDPRTNR VILMSAEDNV VKGAGGQAVQ SFNIMCGFDE TEGLWVL