B2U6V1

PR
Gene name
acsA
Protein name
Acetyl-coenzyme A synthetase
Names
AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme
Species
Ralstonia pickettii (strain 12J)
KEGG Pathway
rpi:Rpic_2099
EC number
6.2.1.1: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

212-284 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2U6V1

Entry ID Method Resolution Chain Position Source
AF-B2U6V1-F1 Predicted AlphaFoldDB

No variants for B2U6V1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2U6V1

No associated diseases with B2U6V1

3 regional properties for B2U6V1

Type Name Position InterPro Accession
domain DNA-binding HTH domain, TetR-type 10 - 70 IPR001647
domain Transcription regulator MAATS, C-terminal 84 - 202 IPR013572
conserved_site DNA-binding HTH domain, TetR-type, conserved site 28 - 58 IPR023772

Functions

Description
EC Number 6.2.1.1 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
acetate-CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
AMP binding Binding to AMP, adenosine monophosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
acetyl-CoA biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGIESVLQE TRVFNPPESF VKQANIAGMD AYRALCAEAE HDYEGFWARL AHEHLLWHKP
70 80 90 100 110 120
FSKVLDESNA PFYKWFEDGE LNASYNCLER NLENGNADKV AIIFETDDGK VSRTTYRELH
130 140 150 160 170 180
ARVCRFANGL KALGIKKGDR VVIYMPMSVE GIVAMQACAR IGATHSVVFG GFSAKSLQER
190 200 210 220 230 240
IVDVGAVALI TADEQMRGGK ALPLKAIADE ALAMEGTDAV KHVIVYRRTN GNVNWVEGRD
250 260 270 280 290 300
RAMDEVEAGQ PDTCEVTPVS AEHPLFILYT SGSTGKPKGV QHSTGGYLLW ALLTMQWTFD
310 320 330 340 350 360
LKPDDIFWCT ADIGWVTGHS YIAYGPLAAG ATQVVFEGVP TYPNAGRFWD MIQRHKVNTF
370 380 390 400 410 420
YTAPTAIRSL IKAAEADEKV HPKQYDLSSL RLLGTVGEPI NPEAWMWYHT NIGGGRCPIV
430 440 450 460 470 480
DTFWQTETGG HMMTPLPGAT PLVPGSCTLP LPGIMAAVVD ETGHDVPNGQ GGILVVKRPW
490 500 510 520 530 540
PSMIRTIWGD PERFKKSYFP EELGGKLYLA GDGSIRDKDT GYFTIMGRID DVLNVSGHRM
550 560 570 580 590 600
GTMEIESALV ANPIVAEAAV VGRPDDMTGE AICAFVVLKR SRPDGDEAKQ IANELRNWVG
610 620 630 640 650
KEIGPIAKPK DIRFGDNLPK TRSGKIMRRL LRSLAKGEDI TQDTSTLENP AILDQLKETR