B2SZN0

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) (Burkholderia phytofirmans)
KEGG Pathway
bpy:Bphyt_2824
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2SZN0

Entry ID Method Resolution Chain Position Source
AF-B2SZN0-F1 Predicted AlphaFoldDB

No variants for B2SZN0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2SZN0

No associated diseases with B2SZN0

4 regional properties for B2SZN0

Type Name Position InterPro Accession
domain DHHA1 domain 733 - 870 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 695 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 554 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 708 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKAAEIREKF LKFFESKGHT IVRSSSLVPG NDPTLLFTNS GMVQFKDVFL GAESRPYSRA
70 80 90 100 110 120
TTAQRSVRAG GKHNDLENVG YTARHHTFFE MLGNFSFGDY FKRDAIHYAW ELLTGVYQLP
130 140 150 160 170 180
KDKLWVTVYH EDDEAHDIWA KEVGVPVERI IRIGDNKGAR YASDNFWQMA DVGPCGPCSE
190 200 210 220 230 240
IFYDHGPDVW GGPPGSPEED GDRYIEIWNL VFMQFSRDAQ GNMTPLPKQC VDTGMGLERI
250 260 270 280 290 300
AAVLQHVHSN YEIDLFQALI KAAGRETGVS DLTNNSLKVI ADHIRACSFL IVDGVIPGNE
310 320 330 340 350 360
GRGYVLRRIV RRAIRHGYKL GKKGSFFHRM VADLVAQMGD AYPELKEAEQ RVTDVLRQEE
370 380 390 400 410 420
ERFFETIEHG MSILESALAD LEAKGGKTLD GELAFKLHDT YGFPLDLTAD VCREREVTVD
430 440 450 460 470 480
EAAFDEAMAR QREQARAAGK FKMAQGLEYS GAKTTFHGYE EIVFDDAKVI ALYVDGASVK
490 500 510 520 530 540
EVRDGRQAVV VLDHTPFYAE SGGQVGDQGV LANASVRFAV SDTLKVQADV VGHHGTLEQG
550 560 570 580 590 600
TLKVGDVVKA EIDAVRRART ARNHSATHLM HKALREVLGS HVQQKGSLVD ADKTRFDFAH
610 620 630 640 650 660
NAPMTDEQIR RVEEIVNAEV LANAPGIVRV MPFDEAVKGG AMALFGEKYG DEVRVLDLGF
670 680 690 700 710 720
SRELCGGTHV HRTGDIGLFK IVMEGGVAAG IRRVEAITGD NAVRFVQDLD ARINAAAAVL
730 740 750 760 770 780
KAQPSELTQR ITQVQDQVKS LEKELSALKS KMASSQGDEL AGQAIEVGGV HVLAATLEGA
790 800 810 820 830 840
DVKTLRETVD KLKDKLKSAA IVLASVEGGK VSLIAGVTAD ASKKVKAGEL VNFVAQQVGG
850 860 870
KGGGRPDMAQ AGGTEPANLP AALAGVKGWV EGQL