B2SGS3

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Francisella tularensis subsp mediasiatica (strain FSC147)
KEGG Pathway
ftm:FTM_1018
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-163 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2SGS3

Entry ID Method Resolution Chain Position Source
AF-B2SGS3-F1 Predicted AlphaFoldDB

No variants for B2SGS3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2SGS3

No associated diseases with B2SGS3

7 regional properties for B2SGS3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 317 - 527 IPR002314
domain TGS 1 - 61 IPR004095
domain Anticodon-binding 539 - 628 IPR004154
domain Aminoacyl-tRNA synthetase, class II 268 - 532 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 168 - 217 IPR012947
domain Threonine-tRNA ligase catalytic core domain 240 - 537 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 537 - 622 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MINIRFPDGS IREFEAGVNS LDVAKSISPS LAKATMAAYI DDQLKDAKDA INSNCELRLI
70 80 90 100 110 120
TVKDPEGLEI LRHSCAHLLA HAVKELYPNT EVTIGPVVDN GFYYDFSFKE SIGEADLPTI
130 140 150 160 170 180
EKKMKELAKK SAPVSYRVVP KAEAIEFFKA QGENYKVEII DSIADEQMKI YTQDNFSDLC
190 200 210 220 230 240
RGPHIPNTSV LKAFKLTKLA GAYWRGNSDN EMLTRIYGTC WATKEDLEQY LNMLEEAEKR
250 260 270 280 290 300
DHRKIGKVLD LFHFQEDSPG IAFWHDNGVR IWRQVEDYMR ASNNKYGCSE IRTPLIADFS
310 320 330 340 350 360
LWQKSGHASK YAENMFATKS ENRDFAIRPM NCPTCVQVYN TKLHSYRDLP IRMAEFGIVH
370 380 390 400 410 420
RNEPSGSLHG LLRVRSFTQD DGHIFCTPEQ VEEEVILMVQ QCFEVYKDFG FNDFAVKIAL
430 440 450 460 470 480
RPENRIGDDE TWDKSEQMLK NALDANNVSY ELLPGEGAFY GPKIEFHLKD AIGRSWQCGT
490 500 510 520 530 540
IQLDFSMPQR LGATYIDKNG EKQVPVMLHR AIVGSLERFI GMLIEHYAGN LPLWLAPVQV
550 560 570 580 590 600
AVMGISNNQD DYCKEVFIML EKNGIRAKLD LRNEKIGFKI REHTLLRVPY LVILGKNEQE
610 620 630
QKIITIRKHS GEDLGQMSVD DFCAFLDKQI QAKE