B2S448

PR
Gene name
rnc
Protein name
Ribonuclease 3
Names
Ribonuclease III, RNase III
Species
Treponema pallidum subsp pallidum (strain SS14)
KEGG Pathway
tpp:TPASS_0809
EC number
3.1.26.3: Endoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2S448

Entry ID Method Resolution Chain Position Source
AF-B2S448-F1 Predicted AlphaFoldDB

No variants for B2S448

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2S448

No associated diseases with B2S448

2 regional properties for B2S448

Type Name Position InterPro Accession
domain Ribonuclease III domain 24 - 175 IPR000999
domain Double-stranded RNA-binding domain 181 - 250 IPR014720

Functions

Description
EC Number 3.1.26.3 Endoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ribonuclease III activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
rRNA binding Binding to a ribosomal RNA.

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLCLGHIFS RSRSPLTPER RESLRRLQET LGVKFRDPTA LDQALSHRSL FSSKEDHCGV
70 80 90 100 110 120
RHNERMEFLG DAVLGAVAAA CLYRALPDSH EGDLAKTKAV LVSTDTLSDI ALSLRIDHYL
130 140 150 160 170 180
LLGKGEELSG GRHKKAILAD ATEAVIGALF LDSGFKAAER FVLRLLLPRV RPIREKNLHH
190 200 210 220 230 240
DYKSTLQVLA HQRYRSKPEY TVVKRTGPDH SVRFWVDVTV GDARFGPGYG TSKKSAEQCA
250
ARLAWEQLSG TLRE