B2RYJ4
Gene name |
Aasdhppt |
Protein name |
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase |
Names |
4'-phosphopantetheinyl transferase, Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase, AASD-PPT |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:300328 |
EC number |
2.7.8.7: Transferases for other substituted phosphate groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B2RYJ4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B2RYJ4-F1 | Predicted | AlphaFoldDB |
No variants for B2RYJ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B2RYJ4 | |||||
No associated diseases with B2RYJ4
1 regional properties for B2RYJ4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 4'-phosphopantetheinyl transferase domain | 125 - 244 | IPR008278 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.8.7 | Transferases for other substituted phosphate groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| holo-[acyl-carrier-protein] synthase activity | Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| 10-formyltetrahydrofolate catabolic process | The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. |
| lysine biosynthetic process via aminoadipic acid | The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. |
| protein maturation | Any process leading to the attainment of the full functional capacity of a protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NRN7 | AASDHPPT | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFPAKRLCV | VPYMEGVRWA | FSCGTWLPSP | AEWLLAVRSI | QPEEKERIGQ | FVFARDAKAA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAGRLMIRKL | VAEKLNIPWD | HIRLQRTSKG | KPILAKDTLN | PYPNFNFNIS | HQGDYTVLAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EPELQVGIDI | MKTSFPGRGS | IPEFFHIMKR | KFTNKEWETI | RSFNDEWSQL | DMFYRHWALK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ESFIKAIGVG | LGFEMQRLEF | DVSPLSMDIG | QVYKETRLIL | DGEEEKEWAF | EESKIDQHHF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAVALRKPDG | SRHQNVSYQD | DSKPSQRQFT | ILNFNDLIAS | AIPMTPEDPS | FWDCFCFTEE |
| ILIRNGSKS |