B2RUR8
PR
Gene name |
Otud7b |
Protein name |
OTU domain-containing protein 7B |
Names |
Cellular zinc finger anti-NF-kappa-B protein, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
mmu:229603 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
183-365 (OTU domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B2RUR8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B2RUR8-F1 | Predicted | AlphaFoldDB |
7 variants for B2RUR8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs33170355 | 51 | N>S | No | Ensembl | |
| rs252983493 | 176 | M>L | No | Ensembl | |
| rs222051347 | 179 | T>P | No | Ensembl | |
| rs260727626 | 478 | G>S | No | Ensembl | |
| rs221086198 | 587 | S>N | No | Ensembl | |
| rs1134803502 | 666 | K>Q | No | Ensembl | |
| rs240449752 | 684 | P>S | No | Ensembl |
No associated diseases with B2RUR8
No regional properties for B2RUR8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for B2RUR8 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| K63-linked polyubiquitin modification-dependent protein binding | Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. |
| Lys48-specific deubiquitinase activity | Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. |
| thiol-dependent deubiquitinase | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| zinc ion binding | Binding to a zinc ion (Zn). |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| adaptive immune response | An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| mucosal immune response | An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. |
| negative regulation of I-kappaB kinase/NF-kappaB signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
| negative regulation of interleukin-8 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. |
| negative regulation of protein localization to nucleus | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| protein deubiquitination involved in ubiquitin-dependent protein catabolic process | The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism. |
| protein K11-linked deubiquitination | A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein. |
| protein K48-linked deubiquitination | A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. |
| protein K63-linked deubiquitination | A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21580 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | Homo sapiens (Human) | SS |
| Q8TE49 | OTUD7A | OTU domain-containing protein 7A | Homo sapiens (Human) | SS |
| Q6GQQ9 | OTUD7B | OTU domain-containing protein 7B | Homo sapiens (Human) | EV |
| Q60769 | Tnfaip3 | Tumor necrosis factor alpha-induced protein 3 | Mus musculus (Mouse) | SS |
| Q8R554 | Otud7a | OTU domain-containing protein 7A | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRPFASAPA | RGHRQGQEER | ERRSEEGGSV | PGPRTFQVVS | PVVTPGQEAT | LFRVEAVEEG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EARHEGDVAG | IGREFQLLAE | DIVEEVEVVA | DEEQEQRPSQ | ELEEKTVEEQ | GQERPGGPCE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RQELDALQAL | AALQVELSSE | REQNRRAYVQ | FMRKNHQRRK | RHLARRSTII | QGIPGFWAKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IMSHPQVSVL | ISDQDQDFLG | YMMDLKVQVR | SHPPSRCKLI | FSFRDNPYFL | NSVIIKEYYL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DITGYRARRS | TPVHWFWDFE | RGAPSRRRDT | RSLNFLNWLS | GHNGPESNRI | AEIISEDVWD |
| 310 | |||||
| DPLKYYLREE | GSSVRDN |