B2KCJ9

PR
Gene name
dxr
Protein name
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Names
DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase
Species
Elusimicrobium minutum (strain Pei191)
KEGG Pathway
emi:Emin_0690
EC number
1.1.1.267: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

124-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2KCJ9

Entry ID Method Resolution Chain Position Source
AF-B2KCJ9-F1 Predicted AlphaFoldDB

No variants for B2KCJ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2KCJ9

No associated diseases with B2KCJ9

3 regional properties for B2KCJ9

Type Name Position InterPro Accession
domain 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal 4 - 130 IPR013512
domain 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal 144 - 230 IPR013644
domain DXP reductoisomerase C-terminal domain 262 - 379 IPR026877

Functions

Description
EC Number 1.1.1.267 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH.
metal ion binding Binding to a metal ion.
NADPH binding Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

2 GO annotations of biological process

Name Definition
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNIVVLGST GSIGVSSLDV IDKLGAGYGV LALSANTNAD LLIKQMLKFK PRFVAVLNED
70 80 90 100 110 120
SYQKVKPYVP ENTKLLPPDE DSLIFLASLP SADLIINGLV GAVGFMPLVT AIKNGKTIAL
130 140 150 160 170 180
ANKEPIVMAG KSIMEECYRW KATILPVDSE PSAIFQCLQG TPAGRKEEDI SRLLLTASGG
190 200 210 220 230 240
PFFKYKGALS RVKPEAALAH PRWVMGKKIT IDSATLMNKG FETIEIMHLF NVSLSDIEIV
250 260 270 280 290 300
IHPQSIIHSA VEFKDGSILA QLSQPDMRLP IQYAVTYPNR MPSPVKKLTV KDMAKLEFAA
310 320 330 340 350 360
PDFKKFPCLE LALWSAQKEG AFPAVLSAAD EIAVDAYLKE KILFTDIPKL IYSVLKETRS
370 380 390
PSGKITISEA AEFDVWAREK AREFLANKKY KKTII