B2J7T9

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
KEGG Pathway
npu:Npun_F4156
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

243-331 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2J7T9

Entry ID Method Resolution Chain Position Source
AF-B2J7T9-F1 Predicted AlphaFoldDB

No variants for B2J7T9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2J7T9

No associated diseases with B2J7T9

6 regional properties for B2J7T9

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 15 - 173 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 437 - 593 IPR002300-2
domain Aminoacyl-tRNA synthetase, class Ia 635 - 674 IPR002300-3
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 714 - 832 IPR013155
domain Leucyl-tRNA synthetase, editing domain 223 - 423 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSRYNPAAI EEKRQKTWLE LGLDKTPSAS NKPKFYALSM FPYPSGSLHM GHVRNYTITD
70 80 90 100 110 120
VIARFKRMQG YRVIHPMGWD AFGLPAENAA IDRGVPPAKW TYQNITQMRQ QLQRLGLSID
130 140 150 160 170 180
WECELATCSP DYYKWTQWIF LQFLQAGLAY QKEAAVNWDP IDQTVLANEQ VDNEGRSWRS
190 200 210 220 230 240
GAIVERKLLR QWFFKITDYA EELLNDLDKL TGWPERVKLM QANWIGKSTG AYLEFPIVGI
250 260 270 280 290 300
DEKIAVYTTR PDTVYGVSYL VLAPEHPLTN RVTTKEQQAA VEVFIKEVSN QSELERTSED
310 320 330 340 350 360
KPKRGIPTGG VAINPFTGEE VPIWIADYVL YEYGTGAVMG VPAHDVRDFK FAKNYDLPIN
370 380 390 400 410 420
FVIASPDDVA GFDLTPTSEI DGITQLVEVD YKQAYTEPGI LINSGAFTGI SSTDAKQAII
430 440 450 460 470 480
EYAEKQDFGK VRVQYRLRDW LISRQRYWGA PIPVIHCPNC GIVPVPDKDL PVQLPEEVEF
490 500 510 520 530 540
TGRCGSPLTQ LESWVNVPCP TCGTPAKRET DTMDTFIDSS WYFLRFPDAK NEQQVFDSSK
550 560 570 580 590 600
VNDWMPVNQY VGGIEHAILH LLYSRFFTKV LRDRGLLNFD EPFQRLLTQG MVQGLTYLNP
610 620 630 640 650 660
NKGGKDKWIP SNLVNSADPR DPQTDEPLQR LYATMSKSKG NGVAPEDVIS KYGIDTARMF
670 680 690 700 710 720
ILFKAPPEKD LEWDEADVEG QFRFLNRVWR LVTDYITAGV SRKKAQSDLT KAEKELRRAI
730 740 750 760 770 780
HTAIQAVTED VEDEYQFNTA ISELMKLSNA LSDADKNSPI YAEGIRTLVI LIAPFAPHIA
790 800 810 820 830 840
DELWHLLGES DSIHTQTWPS FDPAALVADE ITLVIQVMGK TRGAIQVPAQ ADKAALEKYA
850 860 870
RESEIAQRYI EGKEIKKVIV VPGKLVNFVV S