B2HYP8

PR
Gene name
mnmC
Protein name
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC
Names
tRNA mnm(5)s(2)U biosynthesis bifunctional protein
Species
Acinetobacter baumannii (strain ACICU)
KEGG Pathway
abc:ACICU_03175
EC number
2.1.1.61: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

574-623 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2HYP8

Entry ID Method Resolution Chain Position Source
AF-B2HYP8-F1 Predicted AlphaFoldDB

No variants for B2HYP8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2HYP8

No associated diseases with B2HYP8

4 regional properties for B2HYP8

Type Name Position InterPro Accession
conserved_site MnmG-related, conserved site 278 - 292 IPR020595
domain tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, C-terminal 407 - 619 IPR026904
domain MnmG, N-terminal domain 14 - 402 IPR040131
domain tRNA uridine 5-carboxymethylaminomethyl modification enzyme, C-terminal subdomain 550 - 621 IPR047001

Functions

Description
EC Number 2.1.1.61 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.

1 GO annotations of biological process

Name Definition
tRNA wobble base modification The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNKSNRIQTA ELDWESIDGI EVPISKQFGD VYFSKDNGLL ETRHVFLNGN DLSERLANLQ
70 80 90 100 110 120
DFEYFSVGET GFGTGLNILA LWQLWQQVRP NNHSHLHAIS VEKFPLSKAD LIRALNVWDE
130 140 150 160 170 180
LRPLSKQLIE QYPFPLAGCH RLSFPEERFS IDLWLGDAQD IFPSMVKTKA VNAWFLDGFA
190 200 210 220 230 240
PSCNPDMWEQ NVLNNIVRLS DYGTTFASFS VAGILKRGLK AHGVDITRPR GFGHKREMLK
250 260 270 280 290 300
AVWKAPVSEE ILLEPVRDTF QFTQQRIAVI GAGIAGLSTA WAFAQRGHQV TLFERTVPLS
310 320 330 340 350 360
GASGNPLALL NPKLCPIEQS HEHLMTLSWQ HALNFYKNFQ AFRPIQIQQM ALKNAQDLLD
370 380 390 400 410 420
LADQYPADIV TQQTSSLESD YPHILLTEAG AVSPHQLRDE ILQHPGIELK IANITTLISF
430 440 450 460 470 480
ENKVQLKSGN ETTLEADHVV VCCARESAAL FENYPLLKPI RGQVSWVDNS FATLPLNEAY
490 500 510 520 530 540
SYGGYCMQLN TSELILGASF YPNRDDQEVL LDDHVHNFEL IHSVFPHYAK QLPPVEQWQG
550 560 570 580 590 600
RASVRAQSPD YFPLVGKMQN ESRISTFAGL GSKGFLFAPL CSEVLVAQIL GEACPVPKSL
610 620
LQKLDAQRFQ KKVKPKKPYF KSQ