B2G575

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Limosilactobacillus reuteri (strain JCM 1112) (Lactobacillus reuteri)
KEGG Pathway
lrf:LAR_0091
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2G575

Entry ID Method Resolution Chain Position Source
AF-B2G575-F1 Predicted AlphaFoldDB

No variants for B2G575

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2G575

No associated diseases with B2G575

3 regional properties for B2G575

Type Name Position InterPro Accession
domain FMN-dependent dehydrogenase 14 - 356 IPR000262
active_site FMN-dependent alpha-hydroxy acid dehydrogenase, active site 253 - 259 IPR008259
domain FMN hydroxy acid dehydrogenase domain 1 - 360 IPR037396

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDIKKIRQE PDFYKEKLAT RGVKPEEIDE VIALDKKRRE LLQQTETMKA QRNEASKKIG
70 80 90 100 110 120
EAKRNGESAD AAIKETRELG DKIKELDTEV EANDAELHDK MAHLPNVPHD GVPVSLTEDG
130 140 150 160 170 180
AVELRKVGKV RDFDFEPKHH WDIGENLGIL DFDRAGKVSG ARFVYYLGLG AQLERAVYNF
190 200 210 220 230 240
MLDEHMKEGY TEVLPPYIVN ADSMYGTGQF PKFKEGVYQV NGEDMTLIPT AEVPLTNYYR
250 260 270 280 290 300
GEVIPTEELP VYVTALTPSF RSEAGAAGRD TRGLIRMHQF NKVEMVKYTK PENSWDELEK
310 320 330 340 350 360
MTANAENILK KLNLPYHVIT LTTGDMSFTA SETHDLELWM PAQNKYREVS SCSNCLDFQA
370 380 390 400 410 420
RRMHTQYRDE NGKLQYVHTL NGSGLAVGRT VAAILENYQN ADGSVTIPEV LVPYMHGVTK
430
ITKENAVPFR NKVNK