B2FNS1
Gene name |
guaA |
Protein name |
GMP synthase [glutamine-hydrolyzing] |
Names |
GMP synthetase, Glutamine amidotransferase |
Species |
Stenotrophomonas maltophilia (strain K279a) |
KEGG Pathway |
sml:Smlt2072 |
EC number |
6.3.5.2: Carbon--nitrogen ligases with glutamine as amido-N-donor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B2FNS1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B2FNS1-F1 | Predicted | AlphaFoldDB |
No variants for B2FNS1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B2FNS1 | |||||
No associated diseases with B2FNS1
9 regional properties for B2FNS1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 371 - 627 | IPR000719 |
| domain | SH2 domain | 252 - 346 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 372 - 622 | IPR001245 |
| domain | SH3 domain | 187 - 248 | IPR001452 |
| active_site | Tyrosine-protein kinase, active site | 488 - 500 | IPR008266 |
| domain | F-actin binding | 1479 - 1620 | IPR015015 |
| binding_site | Protein kinase, ATP binding site | 377 - 410 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 371 - 622 | IPR020635 |
| domain | Tyrosine-protein kinase ABL, SH2 domain | 250 - 345 | IPR035837 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.5.2 | Carbon--nitrogen ligases with glutamine as amido-N-donor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GMP synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+). |
| pyrophosphatase activity | Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTNIHNDKIL | ILDFGAQYTQ | LIARRIRELG | VYCEIWAWDH | NPAEIAGFGA | KGIILSGGPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STTLPGAPAA | PQEVFDSGLP | IFGICYGMQT | LAAQLGGATE | AADQREFGHA | EVNVINPDAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FKGLSDHGGE | PKLNVWMSHG | DHVSVAPPGF | TITATTDRIP | VAAMANEEKR | WYGVQFHPEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| THTLQGQALL | RRFVVDVCGC | QTLWTAANII | DDQIARVREQ | VGDDEVILGL | SGGVDSSVVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALLHKAIGEK | LTCVFVDTGL | LRWQEGDQVM | AMFAEHMGVK | VVRVNAADRY | FAALEGVSDP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EAKRKIIGNL | FVEIFDEESN | KLKNAKWLAQ | GTIYPDVIES | AGSKTGKAHV | IKSHHNVGGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEHMKLGLVE | PLRELFKDEV | RRLGVELGLP | RTMVYRHPFP | GPGLGVRILG | EVKREYAELL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AKADAIFIDE | LRKADLYDKT | SQAFAVFLPV | KSVGVVGDAR | AYEWVIALRA | VETIDFMTAH |
| 490 | 500 | 510 | 520 | ||
| WAHLPYEFLG | TVSNRIINEL | RGVSRVVYDI | SGKPPATIEW | E |