B2FL33

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Stenotrophomonas maltophilia (strain K279a)
KEGG Pathway
sml:Smlt1743
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

163-233 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2FL33

Entry ID Method Resolution Chain Position Source
AF-B2FL33-F1 Predicted AlphaFoldDB

No variants for B2FL33

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2FL33

No associated diseases with B2FL33

4 regional properties for B2FL33

Type Name Position InterPro Accession
domain DHHA1 domain 740 - 878 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 660 - 703 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 11 - 563 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 7 - 716 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNASAKFTTS QIRSDFLEFF KGKGHTIVPS APLVPGNDPT LLFTNSGMVQ FKDVFLGAEK
70 80 90 100 110 120
RSYVRAADVQ RCLRAGGKHN DLDQVGYTAR HHTFFEMLGN WSFGDYFKKD AIAWAWELLT
130 140 150 160 170 180
QVWKLPAERL LVTVYQTDDE AYALWRDMVG VPEERIVRIG DNKGAPFASD NFWQMADTGP
190 200 210 220 230 240
CGPCTEIFYD HGDHIAGGPP GSPDEDGDRF IEIWNLVFMQ FDRQPDGTLV PLPAPCVDTG
250 260 270 280 290 300
MGLERLAAIL QHVHTNYEID LFQALIRKAS ELTGTADLEN KSLRVIADHI RACSFLIVDG
310 320 330 340 350 360
VLPSNEGRGY VLRRIIRRAL RHGWMLGVRQ PFFSKLVPTL VEQMGEAYPE LPAAVDTVTR
370 380 390 400 410 420
ALQAEEERFA ETLDAGMKIF EDVAGKASNG VIPGVDAFRL YDTYGFPLDL TQDIARERDL
430 440 450 460 470 480
TVDIAGFDAA MEQQRETARA AGKFGGGVTL PAELVATLSP TLFLGYDRLQ ADGLTVLALL
490 500 510 520 530 540
KDGRPVQSAD AGDAVIVITN QTPFYAESGG QVGDTGVLTG NGVRLAVDDT QKFAGQFHGH
550 560 570 580 590 600
VGTLSEGGLK VGDVLSGQVD GERRGATILN HSATHLLHAA LREVLGSHVQ QKGSLVAPDR
610 620 630 640 650 660
LRFDFSHFQP ISAEELAVIE RKVNQQVRAN NAAEVHNMGM QEALDFGAMA LFGEKYGEHV
670 680 690 700 710 720
RVLKMGDYST ELCGGTHVNR TGDIGLFKIT SEGGVSAGVR RIEAVTGQGA LDYVDAEEAR
730 740 750 760 770 780
LAEAAELLGG SAADVVEKIR ALGQRQKQLE RELEAVKAKV AAGATADLSG QAVEVAGVKV
790 800 810 820 830 840
LAARLEGFDA KALRDAMDRL KQQLGDAVIV LAGAQDGKAA LVAGVNGSAM GKVKAGELLS
850 860 870 880
HIASQIGGKG GGRPDLAQGG GEDGPALATA LAAVVEWVSP RL