B2AY28

PR
Gene name
ERB1
Protein name
Ribosome biogenesis protein ERB1
Names
Eukaryotic ribosome biogenesis protein 1
Species
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
KEGG Pathway
pan:PODANSg5664
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-179 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2AY28

Entry ID Method Resolution Chain Position Source
AF-B2AY28-F1 Predicted AlphaFoldDB

No variants for B2AY28

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2AY28

No associated diseases with B2AY28

7 regional properties for B2AY28

Type Name Position InterPro Accession
repeat WD40 repeat 426 - 509 IPR001680-1
repeat WD40 repeat 562 - 602 IPR001680-2
repeat WD40 repeat 646 - 685 IPR001680-3
repeat WD40 repeat 689 - 729 IPR001680-4
repeat WD40 repeat 741 - 784 IPR001680-5
domain BOP1, N-terminal domain 164 - 426 IPR012953
conserved_site WD40 repeat, conserved site 452 - 466 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

1 GO annotations of molecular function

Name Definition
ribonucleoprotein complex binding Binding to a complex of RNA and protein.

2 GO annotations of biological process

Name Definition
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSKPVEKKR KVRDEESDSE SDDELANGLF DGVLEASEDE EDYIPSDEID DVDSESEVSE
70 80 90 100 110 120
GSEDAEEEEE EEEGDDDALL SDDIPSDDEM GKLSKDAEEL EITEPGVDPK PKHQEEEDRN
130 140 150 160 170 180
YKVVKDANGG ERYVYDEIDP VYDSDDSDAQ GPVNTIGNIP LSFYDSYPHI GYDINGKKIM
190 200 210 220 230 240
RPATGDALQS LLDTIEVPKG WTGLTDVNTG NPLNLTQEEL ELVRRVQHGL VPDEGYDPYP
250 260 270 280 290 300
DTVEWFTSKQ ETMPLSAAPE PKRRFLPSKN EAKQVMKLVR AIREGRILPY KPPEEREREE
310 320 330 340 350 360
EEKEEVQFDI WQDEEPAAPN PMHIPAPKLP PPGYEMSYNP PEEYLPTEEE REEWEKTDPE
370 380 390 400 410 420
DREKEFLPQK FNSLRKVPAW GTLVKERFER CMDLYLAPRV RKNRLNIDPN SLLPKLPSPA
430 440 450 460 470 480
ELKPFPTVVQ TIFRGHEGTV RSIAIDPTGV ALATGGSDGT VRVWELLTGR QVWSVKLSSE
490 500 510 520 530 540
DPVYTVRWRP TKDAFVLAAS AGEDVFLMVP PHSSVTPTLD QASRDVLAAG FGYATNGQQP
550 560 570 580 590 600
ATAPGKEPAG KWARPGTKLE DAGVLVRVTV RSAVKVITWH RRGDHFATVS PEGQRSSVAI
610 620 630 640 650 660
HTLSKHLTQI PFRKLHGLAQ TVVFHPLKPL FFVATMRTVR CYDLQKVELV KIVQPGAKWI
670 680 690 700 710 720
SSLDIHSGGD HLIVGSYDRR LLWHDLDLSN RPHKTMRFHP KAIRAVRFHK GGLPLFADAS
730 740 750 760 770 780
DDGTLQIFYG KVPNDQLESP TIVPVKQLKG HKVVNQVGVV DIDWHPREPW CVSAGADGTA
RLWM