B2A865

PR
Gene name
accD (accA, accDA, Nther_0846)
Protein name
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha
Names
ACCase subunits beta/alpha, Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha
Species
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
KEGG Pathway
nth:Nther_0846
EC number
2.1.3.15: Carboxy- and carbamoyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2A865

Entry ID Method Resolution Chain Position Source
AF-B2A865-F1 Predicted AlphaFoldDB

No variants for B2A865

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2A865

No associated diseases with B2A865

3 regional properties for B2A865

Type Name Position InterPro Accession
domain Acetyl-coenzyme A carboxyltransferase, N-terminal 40 - 306 IPR011762
domain Acetyl-coenzyme A carboxyltransferase, C-terminal 317 - 570 IPR011763
domain Acetyl-coA carboxylase zinc finger domain 41 - 66 IPR041010

Functions

Description
EC Number 2.1.3.15 Carboxy- and carbamoyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex.

4 GO annotations of molecular function

Name Definition
acetyl-CoA carboxylase activity Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
carboxyl- or carbamoyltransferase activity Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor).
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
malonyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFKGLFKKTK YISLNPERKT ELRSDQNDNK SNKPHIPDGL WEKCDSCKSI IYAEDLKKNY
70 80 90 100 110 120
HICHECGHHF RIGAQERINQ IIDEDTWVEL DQNIISENPL EFEGYSEKVD KLQKKTELKE
130 140 150 160 170 180
AILTGLGKIN GQQAVIGAMD SRFLMGSMGS VVGEKVTRAI ETGIDENLPV IMFTASGGAR
190 200 210 220 230 240
MQEGIYSLMQ MAKTSAAISK LKDKGLPYIV VLTDPTTGGV TASFAMLGDI ILAEPNALIG
250 260 270 280 290 300
FAGKRVIEQT IKQKLPKEFQ RAEFLLKHGF VDKVINRKEM RNKLSHILKL HKTKQPSRML
310 320 330 340 350 360
DGNDCSYYSS KDASKKASAK SVEEIRQQGK KLTPYDKVKL VRSKERPTSL DYIDNIFEGF
370 380 390 400 410 420
IEFHGDRYFA DDTSIVGGLA FLNGLPVTVI GQQKGRDLQE NIYRNFGMPN PEGYRKAVRL
430 440 450 460 470 480
MQQAEKFNRP IINFVDTSGA GCGKGAEERG QGEAIAQNLY TMSSLKVPII SLVIGEGGSG
490 500 510 520 530 540
GALALTVADE VWMLENSVYS IVSPEGFASI LWKDSSKAKE AADVMKITAQ DLQELQIIDK
550 560 570 580 590 600
ILEEPYQDAS KDGQAMSEII KNNLLKTLDN LSKKETNDLL TKRYEKFRSI GRFIEKSNLD
SSINQ